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The rapid advancement of flexible electronics has driven innovation in wearable respiratory monitoring devices, yet challenges remain in achieving medical-grade precision for quantitative pulmonary function assessment. This study integrates water molecule-responsive flexible sensing technology, wearable devices, and a cloud-based intelligent analysis platform to develop the first medical-grade flexible respiratory sensing system (SFMS). By leveraging the synergistic effect of bionic microcavity differential pressure sensing and humidity-sensitive interfaces, combined with a pressure difference-flux dynamic model, the system enables simultaneous resolution of peak expiratory flow (PEF) and forced vital capacity (FVC), accurately deriving core pulmonary function indicators such as FEV1/FVC. Clinical validation across 454 cases demonstrated high consistency with gold-standard spirometry (intraclass correlation coefficient [ICC] = 0.93–0.97), with 89.7% sensitivity and 92.3% specificity in differentiating chronic obstructive pulmonary disease (COPD) from asthma. Technologically, this work pioneers medical-grade flexible sensing for quantitative pulmonary testing, eliminating dependence on specialized operators through an embedded edge computing architecture that supports real-time cloud data interaction. The system establishes disease-specific profiles through multi-parametric physiological correlation analysis. Practically, its low cost, portability, and user-friendly operation facilitate seamless integration into primary healthcare and home health management, providing technical tools for hierarchical diagnosis and treatment of chronic respiratory diseases. Aligned with WHO's Respiratory Health Action Plan, this innovation enables universal monitoring to advance early screening and long-term disease management. With significant clinical translation potential, it offers a groundbreaking solution for building a comprehensive prevention and control framework for respiratory diseases.
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Keywords:
- flexible sensing /
- respiratory waves /
- quantitative monitoring /
- lung diseases
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[1] Wu R, Ma L, Liu X Y 2022 Adv Sci 9 e2103981
[2] Lu C S, Jiang Z R, Wang X, Li K Y, Lin G Y, Yang Y Q, Lin Y H, Zheng G Y, Xie B S, Liu X Y 2024 Acta Phys Sin 73 038701
[3] Kim D H, Lu N, Ma R, Kim Y S, Kim R H, Wang S, Wu J, Won S M, Tao H, Islam A, Yu K J, Kim T I, Chowdhury R, Ying M, Xu L, Li M, Chung H J, Keum H, McCormick M, Liu P, Zhang Y W, Omenetto F G, Huang Y, Coleman T, Rogers J A 2011 Science 333 838
[4] Wang X, Liu Z, Zhang T 2017 Small 13 1602790
[5] Hammock M L, Chortos A, Tee B C, Tok J B, Bao Z 2013 Adv Mater 25 5997
[6] Someya T, Bao Z, Malliaras G G 2016 Nature 540 379
[7] Gao W, Emaminejad S, Nyein H Y Y, Challa S, Chen K, Peck A, Fahad H M, Ota H, Shiraki H, Kiriya D, Lien D H, Brooks G A, Davis R W, Javey A 2016 Nature 529 509
[8] Lee H, Choi T K, Lee Y B, Cho H R, Ghaffari R, Wang L, Choi H J, Chung T D, Lu N, Hyeon T, Choi S H, Kim D H 2016 Nat Nanotechnol 11 566
[9] Ray T R, Choi J, Bandodkar A J, Krishnan S, Gutruf P, Tian L, Ghaffari R, Rogers J A 2019 Chem Rev 119 5461
[10] Yang Y, Gao W 2019 Chem Soc Rev 48 1465
[11] Wang T, Li Z, Zhang Q, Chen L, Li M 2022 Sensor Actuat A-Phys 335 113010
[12] Zhao Y, Zhang Y, Wang Y, Zhang Q, Liu Z 2022 Adv Sci 9 e2102873
[13] Safiri S, Carson-Chahhoud K, Noori M, Nejadghaderi S A, Sullman M J M, Ahmadian Heris J, Ansarin K, Mansournia M A, Collins G S, Kolahi A A, Kaufman J S 2022 BMJ 378 e069679
[14] GBD 2019 Chronic Respiratory Diseases Collaborators 2023 eClinicalMedicine 59 100975
[15] Wang C, Xu J, Yang L, Xu Y, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Huang K, Yao W, Sun T, Shan G, Yang T, Lin Y, Wu S, Zhu J, Wang R, Shi Z, Zhao J, Ye X, Song Y, Wang Q, Zhou Y, Ding L, Yang T, Chen Y, Guo Y, Xiao F, Lu Y, Peng X, Zhang B, Xiao D, Chen C S, Wang Z, Zhang H, Bu X, Zhang X, An L, Zhang S, Cao Z, Zhan Q, Yang Y, Cao B, Dai H, Liang L, He J 2018 Lancet 391 1706
[16] Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Global Strategy for the Diagnosis Management and Prevention of Chronic Obstructive Pulmonary Disease (2023 Report) Available at https://goldcopd.org
[17] Pellegrino R, Viegi G, Brusasco V, Crapo R O, Burgos F, Casaburi R, Coates A, van der Grinten C P, Gustafsson P, Hankinson J, Jensen R, Johnson D C, MacIntyre N, McKay R, Miller M R, Navajas D, Pedersen O F, Wanger J 2005 Eur Respir J 26 948
[18] Miller M R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten C P, Gustafsson P, Jensen R, Johnson D C, MacIntyre N, McKay R, Navajas D, Pedersen O F, Pellegrino R, Viegi G, Wanger J, ATS/ERS Task Force 2005 Eur Respir J 26 319
[19] Celli B R, MacNee W, ATS/ERS Task Force 2004 Eur Respir J 23 932
[20] Vestbo J, Hurd S S, Agustí A G, Jones P W, Vogelmeier C, Anzueto A, Barnes P J, Fabbri L M, Martinez F J, Nishimura M, Stockley R A, Sin D D, Rodriguez-Roisin R 2013 Am J Respir Crit Care Med 187 347
[21] Li H, Zhao X, Wang Y, Lou X, Chen S, Deng H, Shi L, Xie J, Tang D, Zhao J, Bouchard L S, Xia L, Zhou X 2021 Sci Adv 7 eabc8180
[22] Li H, Li H, Zhang M, Huang C, Zhou X 2024 5 100720
[23] Rao Q, Li H, Zhou Q, Zhang M, Zhao X, Shi L, Xie J, Fan L, Han Y, Guo F, Liu S, Zhou X 2024 Eur Radiol 34 7450
[24] Quanjer P H, Stanojevic S, Cole T J, Baur X, Hall G L, Culver B H, Enright P L, Hankinson J L, Ip M S, Zheng J, Stocks J 2012 Eur Respir J 40 1324
[25] Levy M L, Quanjer P H, Booker R, Cooper B G, Holmes S, Small I 2009 Prim Care Respir J 18 130
[26] Eaton T, Withy S, Garrett J E, Mercer J, Whitlock R M L, Rea H H 1999 Chest 116 416
[27] Enright P L, Crapo R O 2000 Clin Chest Med 21 645
[28] Johnston K, Grimmer-Somers K, Young M 2010 BMC Res Notes 3 321
[29] Wanger J, Clausen J L, Coates A, Pedersen O F, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten C P, Gustafsson P, Hankinson J, Jensen R, Johnson D, Macintyre N, McKay R, Miller M R, Navajas D, Pellegrino R, Viegi G 2005 Eur Respir J 26 511
[30] Kano S, Burton D L, Lanteri C J 1993 Med Eng Phys 15 365
[31] Farré R, Montserrat J M, Navajas D 1998 Eur Respir J 12 1152
[32] MacIntyre N R, Cheng K C 2002 Respir Care 47 193
[33] Jin L, Liu Z K, Altintas M, Zheng Y, Liu Z C, Yao S R, Fan Y Y, Li Y 2022 ACS Sens 7 2281
[34] Sanchez-Perez J A, Berkebile J A, Nevius B N, Ozmen G C, Nichols C J, Ganti V G, Mabrouk S A, Clifford G D, Kamaleswaran R, Wright D W et al 2022 Sensors 22 1130
[35] Bai S, Chen J 2019 Sensor Actuat B-Chem 298 126908
[36] Yao R Q, Zhou Y T, Shi H, Wan W B, Zhang Q H, Gu L, Wen Z, Lang X Y, Jiang Q 2020 Adv Mater 32 1907214
[37] Lian Y, Yu H, Wang M, Yang X, Zhang H 2020 Nanoscale Res Lett 15 70
[38] Zhang L, Chen X 2020 ACS Appl Mater Interfaces 12 34256
[39] Lee Y K, Park S H 2022 J Biomed Opt 27 550
[40] Ma L, Liu Q, Wu R, Meng Z, Patil A, Yu R, Yang Y, Zhu S, Fan X, Hou C, Li Y, Qiu W, Huang L, Wang J, Lin N, Wan Y, Hu J, Liu X Y 2020 Small 16 2070147
[41] Qian Q, Wu W, Peng L, Wang Y, Tan A M Z, Liang L, Hus S M, Wang K, Choudhury T H, Redwing J M, Puretzky A A, Geohegan D B, Hennig R G, Ma X, Huang S 2022 ACS Nano 16 7428
[42] Pan X, Grossiord N, Sol J A H P, Debije M G, Schenning A P H J 2021 Adv Funct Mater 31 2100465
[43] Lu L, Ding W, Liu J, Yang B 2020 Nano Energy 78 105251
[44] Ma L, Wu R, Patil A, Zhu S, Meng Z, Meng H, Hou C, Zhang Y, Liu Q, Yu R, Wang J, Lin N, Liu X Y 2019 Adv Funct Mater 29 1904549
[45] Zhang L, Zhu Y, Nie Z, Li Z, Ye Y, Li L, Hong J, Bi Z, Zhou Y, Hu G 2023 Adv Mater 35 2209876
[46] Hao F, Wang B, Wang X, Tang T, Li Y, Yang Z, Lu J 2022 Nano Energy 103 107823
[47] Han B, Zheng R, Zeng H, Wang S, Sun K, Chen R, Li L, Wei W, He J 2024 Natl Cancer Cent 4 47
[48] Culver B H, Graham B L, Coates A L, Wanger J, Berry C E, Clarke P K, Hallstrand T S, Hankinson J L, Kaminsky D A, MacIntyre N R, McCormack M C, Rosenfeld M, Stanojevic S, Weiner D J, ATS Committee on Proficiency Standards for Pulmonary Function Laboratories 2017 Am J Respir Crit Care Med 196 1463
[49] Ruppel G L, Enright P L 2012 Respir Care 57 165
[50] Graham B L, Steenbruggen I, Miller M R, Barjaktarevic I Z, Cooper B G, Hall G L, Hallstrand T S, Kaminsky D A, McCarthy K, McCormack M C, Oropez C E, Rosenfeld M, Stanojevic S, Swanney M P, Thompson B R 2019 Am J Respir Crit Care Med 200 e70
[51] Mortimer K M, Fallot A, Balmes J R, Tager I B 2003 Chest 123 1899
[52] Zhang S Q, Lin J, Yu C, Guo Z L, Tang C C, Huang Y 2025 Sensor Actuat B-Chem 437 137744
[53] Lu C S, Wang X, Li K Y, Lin G Y, Yang Y Q, Lin Y H, Zheng G Y, Xie B S, Jiang Z. Xu Z, Liu Y, Ke S, Zhang B, Han K, Huang Y, Cui L, Liu X Y Adv. Fibers Mater to be published.
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