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This paper developed a 4 array transducers photoacoustic endoscopic probe, and based on this, a photoacoustic endoscopic imaging system was build. Phantom experimental imaging was carried out, and the capability of location for endoscopic probe was demonstrated via analyzing the absorption of the light on the 4 sensors position. The in vitro human normal tissues and early colorectal cancer tissues was imaged using photoacoustic endoscopic system. The statistical analysis of the light absorbtion intensity distribution on different position proved that the photoacoustic endoscopic system has the ability to distinguish human normal tissues and early colorectal cancer tissues. This technology is expected to improve the accuracy of early diagnosis of colorectal cancer and has the potential clinical application.
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Keywords:
- transducer /
- photoacoustic endoscopy /
- colorectal cancer
[1] Xiang L Z, Wang B, Ji L, Jiang H B 2013 Sci. Rep. 3 1113
[2] Xi L, Grobmyer S R, Zhou G, Qian W, Yang L, Jiang H B 2012 J. Biophoton. DOI: 10.1002/jbio. 201200155
[3] Yuan Z, Zhang Q, Jiang H B 2006 Opt. Express 14 6749
[4] Jiao S, Jiang M, Hu J, Fawzi A, Zhou Q, Shung K K, Puliafito C A, Zhang H F 2010 Opt. Express 18 3967
[5] Yang J M, Maslov K, Yang H C, Zhou Q, Shung K K, Wang L V 2009 Opt. Lett. 34 1591
[6] Wang S H, Tao C, Liu X J 2013 Chin. Phys. B 22 074303
[7] Yuan Y, Yang S, Xing D 2010 Opt. Lett. 35 2266
[8] Weia W, Li X, Zhou Q F, Shungb K K, Chen Z P 2011 Proc. SPIE 7893 789314
[9] Wang B, Karpiouk A, Yeager D, Amirian J, Litovsky S, Smalling R, Emelianov S 2011 Opt. Lett. 37 1244
[10] Jansen K, van der Steen A F W, van Beusekom H M M, Oosterhuis J W, van Soest G 2011 Opt. Lett. 36 597
[11] Allen T J, Beard P C 2009 Proc. SPIE 7177 71770A
[12] Yang J M, Favazza C, Chen R M, Yao J J, Cai X, Maslov K, Zhou Q F, Shung K K, Wang L V 2012 Nat. Med. 18 1297
[13] Yang J Mo, Maslov K, Chen R M 2010 Proc. SPIE 7564 754640D
[14] Yang J M, Favazza C, Chen R M 2011 Proc. SPIE 7889 78890D
[15] Aguirre A, Guo P Y, Gamelin J, Yan S, Sanders M M, Brewer M, Zhu Q 2009 J. Biomed. Opt. 14 054014
[16] Yang D W, Xing D, Yang S H, Xiang L Z 2007 Opt. Express 15 15566
[17] Ye F, Yang S H, Xing D 2010 Appl. Phys. Lett. 97 213702
[18] Yuan Y, Yang S H, Xing D 2011 J. Appl. Phys. 110 054701
[19] Chen B Z, Chu F T, Liu X Z, Li Y R, Rong J, Jiang H B 2013 Appl. Phys. Lett. 103 031118
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[1] Xiang L Z, Wang B, Ji L, Jiang H B 2013 Sci. Rep. 3 1113
[2] Xi L, Grobmyer S R, Zhou G, Qian W, Yang L, Jiang H B 2012 J. Biophoton. DOI: 10.1002/jbio. 201200155
[3] Yuan Z, Zhang Q, Jiang H B 2006 Opt. Express 14 6749
[4] Jiao S, Jiang M, Hu J, Fawzi A, Zhou Q, Shung K K, Puliafito C A, Zhang H F 2010 Opt. Express 18 3967
[5] Yang J M, Maslov K, Yang H C, Zhou Q, Shung K K, Wang L V 2009 Opt. Lett. 34 1591
[6] Wang S H, Tao C, Liu X J 2013 Chin. Phys. B 22 074303
[7] Yuan Y, Yang S, Xing D 2010 Opt. Lett. 35 2266
[8] Weia W, Li X, Zhou Q F, Shungb K K, Chen Z P 2011 Proc. SPIE 7893 789314
[9] Wang B, Karpiouk A, Yeager D, Amirian J, Litovsky S, Smalling R, Emelianov S 2011 Opt. Lett. 37 1244
[10] Jansen K, van der Steen A F W, van Beusekom H M M, Oosterhuis J W, van Soest G 2011 Opt. Lett. 36 597
[11] Allen T J, Beard P C 2009 Proc. SPIE 7177 71770A
[12] Yang J M, Favazza C, Chen R M, Yao J J, Cai X, Maslov K, Zhou Q F, Shung K K, Wang L V 2012 Nat. Med. 18 1297
[13] Yang J Mo, Maslov K, Chen R M 2010 Proc. SPIE 7564 754640D
[14] Yang J M, Favazza C, Chen R M 2011 Proc. SPIE 7889 78890D
[15] Aguirre A, Guo P Y, Gamelin J, Yan S, Sanders M M, Brewer M, Zhu Q 2009 J. Biomed. Opt. 14 054014
[16] Yang D W, Xing D, Yang S H, Xiang L Z 2007 Opt. Express 15 15566
[17] Ye F, Yang S H, Xing D 2010 Appl. Phys. Lett. 97 213702
[18] Yuan Y, Yang S H, Xing D 2011 J. Appl. Phys. 110 054701
[19] Chen B Z, Chu F T, Liu X Z, Li Y R, Rong J, Jiang H B 2013 Appl. Phys. Lett. 103 031118
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