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Photoacoustic imaging is an advanced medical imaging technology based on the effect of ultrasound generation by electromagnetic irradiation. However in photoacoustic imaging, because the optical property of tissue is always very complex, the aberration of light in tissue is ineluctable and the image spot is dispersed, which greatly influences the photoacoustic image resolution. For improving the lateral resolution of photoacoustic imaging, the adaptive optics multispectral photoacoustic imaging system is proposed in this paper. In this system an adaptive optics sub-system is designed to correct the wavefront errors of the illuminating light for obtaining high-resolution images of biological tissues. Moreover, the multispectral imaging is combined to obtain different wavelength photoacoustic images, which is useful for distinguishing organization accurate structure, identifying organizational components, etc. The simulation results demonstrate that when the wavefront errors are corrected by the adaptive optics system, the image resolution and quality are improved significantly. This research will be helpful for improving the ability and application of photoacoustic imaging.
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Keywords:
- photoacoustic imaging /
- adaptive optics /
- multispectral imaging
[1] Rosencwaig A 1975 Phys. Today 28 9
[2] Yang S H, Yin G Z 2009 Acta Phys. Sin. 58 4765 (in Chinese) [杨思华, 阴广志 2009 58 4765]
[3] Xu X H, Li H 2008 Acta Phys. Sin. 57 4628 (in Chinese) [ 徐晓辉, 李晖 2008 57 4628]
[4] Xu M, Wang L V 2006 Rev. Sci. Instrum. 77 041101-1
[5] Beard P 2011 Interface Focus 1 4
[6] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5850 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5850]
[7] Wang L V 2009 Nat. Photo. 3 9
[8] Xiang L Z, Xing D, Gu H M, Yang S H, Zeng L M 2007 Acta Phys. Sin. 56 3916 (in Chinese) [向良忠, 邢达, 谷怀民, 杨思华, 曾吕明 2007 56 3916]
[9] Li C, Wang L V 2009 Phys. Med. Bio. 54 59
[10] Song K H, Stein E W, Margenthaler J A, Wang L V 2008 J. Biomed. Opt. 13 024006
[11] Wang X D, Pang Y J, Ku G, Xie X Y, Stoica G, Wang L V 2003 Nat. Biotechnol. 21 7
[12] Jiao S, Jiang M, Hu J, Fawzi A, Zhou Q, Shung K K, Puliafito C A, Zhang H F 2010 Opt. Express 18 4
[13] Zhang H F, Maslov K, Stoica G, Wang L V 2006 Nat. Biotechnol. 24 7
[14] Roddier F 1999 Adaptive Optics in Astronomy (London: Cambridge University Press) p22
[15] Liang J, Williams D R, Miller D T 1997 JOSA A 14 11
[16] Zawadzki R, Jones S, Olivier S, Zhao M, Bower B, Izatt J, Choi S, Laut S, Werner J 2005 Opt. Express 13 21
[17] Razansky D, Distel M, Vinegoni C, Ma R, Perrimon N, Kster R W, Ntziachristos V 2009 Nat. Photonics 3 7
[18] West G A, Barrett J J, Siebert D R, Reddy K V 1983 Rev. Sci. Instrum. 54 797
[19] Duck F A 1990 Physical Properties of Tissue: A Comprehensive Reference Book (New York: Academic Press) p102
[20] Ma R, Taruttis A, Ntziachristos V, Razansky D 2009 Opt. Express 17 24
[21] Wang S F 2003 The Theory and Application of Information Optics (Beijing: Beijing University of Posts and Telecommunications) p89 (in Chinese) [王仕璠 2003 信息光学理论与应用 (北京: 北京邮电大学出版社) 第89页]
[22] Keijzer M, Richards-Kortum R R, Jacques S L, Feld M S 1989 Appl. Opt. 28 20
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[1] Rosencwaig A 1975 Phys. Today 28 9
[2] Yang S H, Yin G Z 2009 Acta Phys. Sin. 58 4765 (in Chinese) [杨思华, 阴广志 2009 58 4765]
[3] Xu X H, Li H 2008 Acta Phys. Sin. 57 4628 (in Chinese) [ 徐晓辉, 李晖 2008 57 4628]
[4] Xu M, Wang L V 2006 Rev. Sci. Instrum. 77 041101-1
[5] Beard P 2011 Interface Focus 1 4
[6] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5850 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5850]
[7] Wang L V 2009 Nat. Photo. 3 9
[8] Xiang L Z, Xing D, Gu H M, Yang S H, Zeng L M 2007 Acta Phys. Sin. 56 3916 (in Chinese) [向良忠, 邢达, 谷怀民, 杨思华, 曾吕明 2007 56 3916]
[9] Li C, Wang L V 2009 Phys. Med. Bio. 54 59
[10] Song K H, Stein E W, Margenthaler J A, Wang L V 2008 J. Biomed. Opt. 13 024006
[11] Wang X D, Pang Y J, Ku G, Xie X Y, Stoica G, Wang L V 2003 Nat. Biotechnol. 21 7
[12] Jiao S, Jiang M, Hu J, Fawzi A, Zhou Q, Shung K K, Puliafito C A, Zhang H F 2010 Opt. Express 18 4
[13] Zhang H F, Maslov K, Stoica G, Wang L V 2006 Nat. Biotechnol. 24 7
[14] Roddier F 1999 Adaptive Optics in Astronomy (London: Cambridge University Press) p22
[15] Liang J, Williams D R, Miller D T 1997 JOSA A 14 11
[16] Zawadzki R, Jones S, Olivier S, Zhao M, Bower B, Izatt J, Choi S, Laut S, Werner J 2005 Opt. Express 13 21
[17] Razansky D, Distel M, Vinegoni C, Ma R, Perrimon N, Kster R W, Ntziachristos V 2009 Nat. Photonics 3 7
[18] West G A, Barrett J J, Siebert D R, Reddy K V 1983 Rev. Sci. Instrum. 54 797
[19] Duck F A 1990 Physical Properties of Tissue: A Comprehensive Reference Book (New York: Academic Press) p102
[20] Ma R, Taruttis A, Ntziachristos V, Razansky D 2009 Opt. Express 17 24
[21] Wang S F 2003 The Theory and Application of Information Optics (Beijing: Beijing University of Posts and Telecommunications) p89 (in Chinese) [王仕璠 2003 信息光学理论与应用 (北京: 北京邮电大学出版社) 第89页]
[22] Keijzer M, Richards-Kortum R R, Jacques S L, Feld M S 1989 Appl. Opt. 28 20
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