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基于光声效应的光声光谱技术是光学与声学的有机结合, 可利用不同波长的入射光波, 产生不同的光声信号, 从而为组分识别、组织无损检测等提供高对比度图像, 是一种极具潜力的新型医学诊断技术.但光声光谱检测技术由于受检测方法的制约, 往往扫描时间较长, 而且信号的稳定性和图像识别的准确性也较差. 为了弥补单一光声光谱分析的局限性, 根据光声效应原理和振动理论, 提出了一种光声光谱与光声频谱相结合的双谱分析方法. 该方法通过光声频域信息的定量分析, 可以有效地提高不同组织的光声图像对比度, 从而提高光声成像的组分识别能力, 为光声频谱功能成像奠定理论基础. 实验结果显示, 光声光谱与光声频谱相结合的双谱分析方法可以较好地识别实验组织样品, 可实现高速、高分辨率的组分识别、组织探伤等, 具有广泛的应用前景和重要的临床诊断意义.Photoacoustic spectroscopy based on the photoacoustic effect is the combination of optical imaging and acoustical imaging, which has become a powerful medical diagnosis tool to distinguish different tissues and components with several different wavelength photoacoustic images. But photoacoustic spectroscopy is limited by the scanning speed, system stability and signal accuracy. To solve these limitation problems, in this paper we propose a new method called photoacoustic double spectrum analysis which can greatly improve the image contrast and identification capability with quantitative analysis of the detected photoacoustic signal frequency. The final experimental results indicate that this method has the feasibility to distinguish different tissues quickly and easily with better contrast, which will be helpful for improving the applications of photoacoustic imaging in various branches of physics, biology, engineering, medicine, etc. We also expect the theoretical and experimental research proposed in this paper to establish the foundation and method for photoacoustic frequency imaging.
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Keywords:
- photoacoustic imaging /
- photoacoustic spectrum /
- spectral analysis of photoacoustic frequency
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[2] Li J 2010 Modern Instrum. 16 31 (in Chinese) [李军 2010 现代仪器 16 31]
[3] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5850 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5850]
[4] Xiang L Z, Xing D, Gu H M, Yang S H, Zeng L M 2007 Acta Phys. Sin. 56 3916 (in Chinese) [向良忠, 邢达, 谷怀民, 杨思华, 曾吕明 2007 56 3916]
[5] Jian X H, Cui Y Y, Xiang Y J, Han Z L 2012 Acta Phys. Sin. 61 217801 (in Chinese) [简小华, 崔崤峣, 向永嘉, 韩志乐 2012 61 217801]
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[7] Xu X H, Li H 2008 Acta Phys. Sin. 57 4628 (in Chinese) [徐晓辉, 李晖2008 57 4628]
[8] Kruger R A, Liu P, Appledorn C R 1995 Med. Phys. 22 1605
[9] Kruger R A, Stantz K, Kiser Jr W L 2002 Proc. SPIE 521
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[11] Ku G, Wang L V 2005 Opt. Lett. 30 507
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[13] Ku G, Wang X, Xie X, Stoica G, Wang L V 2005 Appl. Opt. 44 770
[14] Xu M, Wang L V 2006 Rev. Sci. Instrum. 77 041101
[15] Yang D, Xing D, Gu H, Tan Y, Zeng L 2005 Appl. Phys. Lett. 87 194101
[16] Yin B, Xing D, Wang Y, Zeng Y, Tan Y, Chen Q 2004 Phys. Med. Biol. 49 1339
[17] Zeng Y G, Xing D, Fu H B, Wang Y 2005 Chin. J. Lasers 32 97 (in Chinese) [曾亚光, 邢达, 付洪波, 王毅 2005 中国激光 32 97]
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[19] Zhang J, Yang S H 2010 Chin. J. Lasers 38 104001 (in Chinese) [张建, 杨思华 2010 中国激光 38 104001]
[20] Tan Y, Xing D, Wang Y, Zeng Y G, Yi B Z 2005 Acta Photon. Sin. 34 1019 (in Chinese) [谭毅, 邢达, 王毅, 曾亚光, 尹邦政 2005 光子学报 34 1019]
[21] Qian S Y, Xing D 2000 Acta Laser Biol. 9 228 (in Chinese) [钱盛友, 邢达 2000激光生物学报 9 228]
[22] Michels R, Foschum F, Kienle A 2008 Opt. Express 16 5907
[23] Prahl S 1999 Oregon Medical Laser Center 15 277
[24] Hoelen C, de Mul FFM 1999 J. Acoust. Soc. Am. 106 695
[25] Song Z Y 2009 Ph. D. Dissertation (Tianjin:Tianjin University) (in Chinese) [宋智源 2009 博士学位论文 (天津:天津大学)]
[26] Hu H Y, Sun J H, Chen H H 1998 Mechanical Vibration and Shock (1st Ed.) (Beijing:Aviation Industry Press) (in Chinese) [胡海岩, 孙久厚, 陈怀海 1998 机械振动与冲击 (第1版) (北京:航空工业出版社)]
[27] Hu H Y 1992 J. Vib. Eng. 5 8 (in Chinese) [胡海岩1992振动工程学报 5 8]
[28] Fan H D, Fu J M, Zhou X M, Zhao H 2004 Nondestruc. Test. 26 551 (in Chinese) [范海东, 傅金明, 周小明, 赵晗 2004 无损检测 26 551]
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[1] Bell A G 1980 Am. J. Sci. Arts Ser. 3 305
[2] Li J 2010 Modern Instrum. 16 31 (in Chinese) [李军 2010 现代仪器 16 31]
[3] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5850 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5850]
[4] Xiang L Z, Xing D, Gu H M, Yang S H, Zeng L M 2007 Acta Phys. Sin. 56 3916 (in Chinese) [向良忠, 邢达, 谷怀民, 杨思华, 曾吕明 2007 56 3916]
[5] Jian X H, Cui Y Y, Xiang Y J, Han Z L 2012 Acta Phys. Sin. 61 217801 (in Chinese) [简小华, 崔崤峣, 向永嘉, 韩志乐 2012 61 217801]
[6] Li C, Wang L V 2009 Phys. Med. Biol. 54 R59
[7] Xu X H, Li H 2008 Acta Phys. Sin. 57 4628 (in Chinese) [徐晓辉, 李晖2008 57 4628]
[8] Kruger R A, Liu P, Appledorn C R 1995 Med. Phys. 22 1605
[9] Kruger R A, Stantz K, Kiser Jr W L 2002 Proc. SPIE 521
[10] Hoelen C, De Mul F, Pongers R, Dekker A 1998 Opt. Lett. 23 648
[11] Ku G, Wang L V 2005 Opt. Lett. 30 507
[12] Ku G, Wang X, Stoica G, Wang L V 2004 Phys. Med. Biol. 49 1329
[13] Ku G, Wang X, Xie X, Stoica G, Wang L V 2005 Appl. Opt. 44 770
[14] Xu M, Wang L V 2006 Rev. Sci. Instrum. 77 041101
[15] Yang D, Xing D, Gu H, Tan Y, Zeng L 2005 Appl. Phys. Lett. 87 194101
[16] Yin B, Xing D, Wang Y, Zeng Y, Tan Y, Chen Q 2004 Phys. Med. Biol. 49 1339
[17] Zeng Y G, Xing D, Fu H B, Wang Y 2005 Chin. J. Lasers 32 97 (in Chinese) [曾亚光, 邢达, 付洪波, 王毅 2005 中国激光 32 97]
[18] Yang D W, Xing D, Zhao X H 2010 Chin. Phys. Lett. 27 144
[19] Zhang J, Yang S H 2010 Chin. J. Lasers 38 104001 (in Chinese) [张建, 杨思华 2010 中国激光 38 104001]
[20] Tan Y, Xing D, Wang Y, Zeng Y G, Yi B Z 2005 Acta Photon. Sin. 34 1019 (in Chinese) [谭毅, 邢达, 王毅, 曾亚光, 尹邦政 2005 光子学报 34 1019]
[21] Qian S Y, Xing D 2000 Acta Laser Biol. 9 228 (in Chinese) [钱盛友, 邢达 2000激光生物学报 9 228]
[22] Michels R, Foschum F, Kienle A 2008 Opt. Express 16 5907
[23] Prahl S 1999 Oregon Medical Laser Center 15 277
[24] Hoelen C, de Mul FFM 1999 J. Acoust. Soc. Am. 106 695
[25] Song Z Y 2009 Ph. D. Dissertation (Tianjin:Tianjin University) (in Chinese) [宋智源 2009 博士学位论文 (天津:天津大学)]
[26] Hu H Y, Sun J H, Chen H H 1998 Mechanical Vibration and Shock (1st Ed.) (Beijing:Aviation Industry Press) (in Chinese) [胡海岩, 孙久厚, 陈怀海 1998 机械振动与冲击 (第1版) (北京:航空工业出版社)]
[27] Hu H Y 1992 J. Vib. Eng. 5 8 (in Chinese) [胡海岩1992振动工程学报 5 8]
[28] Fan H D, Fu J M, Zhou X M, Zhao H 2004 Nondestruc. Test. 26 551 (in Chinese) [范海东, 傅金明, 周小明, 赵晗 2004 无损检测 26 551]
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