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Because of the special structure and intracellular functions of myosin Ⅵ molecular motor, its dynamic principle has become a research focus. Starting from its structure and experimental phenomenon, the elastic-diffusion model of myosin Ⅵ in a periodic potential field is established, and the stochastic dynamics of the molecular motors, which conform to the Langevin equation, is analyzed by Monte Carlo simulations. By means of the environmental noise, myosin Ⅵ molecular motors could take stable stepping motion and effective transport according to its elastic potential energy and periodic potential of track, and a load can weaken the transportation power of the molecular motor system. For a given elastic coefficient, the longer the elastic chain of myosin Ⅵ, the lower the average velocity of it. By selecting a reasonable size of elasticity coefficient, the average velocity can be the maximum for a given elastic chain. In addition, the load can increase exponentially the mean dwelling time of myosin Ⅵ at the connection site.
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Keywords:
- molecular motor /
- Myosin Ⅵ /
- Langevin equation /
- elastic-diffusion model
[1] Rogat A D, Miler K G 2002 Journal of Cell Sciencs 115 4855
[2] Hasson T, Gillespie P G, Garcia J A, MacDonald R B, Zhao Y D, Yee A G, Mooseker M S, Corey D P 1997 Journal of Cell Biology 137 1287
[3] Nishikawa S, Homma K, Komori Y, Iwaki M, Wazawa T, Iwone A H, Saito J, Ikebe R, Katayama E, Yanagida T, Ikebe M 2002 Biochemical Biophysical Rresearch Communications 290 311
[4] Lister I, Schmitz S, Walker M, Trinick J, Buss F, Veigel C, Kendrick-Jones J 2004 EMBO Journal 23 1729
[5] Rock R S, Ramamurthy B, Dunn A R, Beccafico S, Rami B R, Morris C, Spink B J, Franzini-Armstrong C, Spudich J A, Sweeney H L 2005 Molecular Cell 17 603
[6] Xie P, Dou S X, Wang P Y 2005 Chin. Phys. 14 744
[7] Xie P, Dou S X, Wang P Y 2005 Biophysical Chemistry 122 90
[8] Bahloul A, Chevreux G, Wells A L, Martin D, Nolt J, Yang Z H, Chen L Q, Potier N, Dorsselaer A V, Rosenfeld S, Houdusse H, Sweeney H L 2004 PNAS 101 4787
[9] Hasson T, Mooseker E M 1994 Journal of Cell Biology 127 425
[10] Ménétrey J, Bahloul A, Wells A L, Yengo C M, Morris C A, Sweeney H L, Houdusse A 2005 Nature 435 779
[11] Park H, Li A, Chen L Q, Houdusse A, Selvin P R, Sweeney H L 2007 PNAS 104 778
[12] Altman D, Sweeney H L, Spudich J A 2004 Cell 116 737
[13] De La Cruz E M, Ostap E M, Sweeney H L 2001 Journal of Biological Chemistry 276 32373
[14] Reifenberger J G, Toprak E, Kim H J, Safer D, Sweeney H L, Selvin P R 2009 PNAS 106 18255
[15] Bao J D, Zhuo Y Z 1998 Chinese Science Bulletin 43 1493
[16] Bao J D 1997 Chinese Journal of Computational Physics 14 463 (in Chinese) [包景东 1997 计算物理 14 463]
[17] Marchesoni F 1997 Physical Review E 56 2497
[18] Guo C, Yin Y H 2010 Chinese Science Bulletin 55 2675 (in Chinese) [郭朝, 殷跃红 2010 科学通报 55 2675]
[19] Kolomeisky A B, Fisher M E 2003 Biophysical Journal 84 1642
[20] Xu W, Zhang X Y 2007 Chin. Phys. 16 928
[21] Wang H Y, Bao J D 2010 Physica A 389 433
[22] Li F Z, Su W F, Hu K H 2009 Acta Biophysica Sinica 25 133 (in Chinese) [李防震, 苏万芳, 胡匡祜 2009 生物 25 133]
[23] Feng J, Zhuo Y Z 2005 Chin. Phys. Lett. 22 503
[24] Chen Z X 2003 Computational physics (Vol. 2) (Harbin: Harbin Institute of Technology Press) p92 (in Chinese) [陈锺贤 2003 计算物理学(第二版)(哈尔滨: 哈尔滨工业大学出版社)第92页]
[25] Bao J D 2009 Stochastic simulation method of classical and quantum dissipative systems (BeiJing: Science Press) p113 (in Chinese) [包景东 2009 经典和量子耗散系统的随机模拟方法(北京: 科学出版社)第113页]
[26] Spudich J A, Sivaramakrishnan S 2010 Nature Reviews Molecular Cell Biology 11 128
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[1] Rogat A D, Miler K G 2002 Journal of Cell Sciencs 115 4855
[2] Hasson T, Gillespie P G, Garcia J A, MacDonald R B, Zhao Y D, Yee A G, Mooseker M S, Corey D P 1997 Journal of Cell Biology 137 1287
[3] Nishikawa S, Homma K, Komori Y, Iwaki M, Wazawa T, Iwone A H, Saito J, Ikebe R, Katayama E, Yanagida T, Ikebe M 2002 Biochemical Biophysical Rresearch Communications 290 311
[4] Lister I, Schmitz S, Walker M, Trinick J, Buss F, Veigel C, Kendrick-Jones J 2004 EMBO Journal 23 1729
[5] Rock R S, Ramamurthy B, Dunn A R, Beccafico S, Rami B R, Morris C, Spink B J, Franzini-Armstrong C, Spudich J A, Sweeney H L 2005 Molecular Cell 17 603
[6] Xie P, Dou S X, Wang P Y 2005 Chin. Phys. 14 744
[7] Xie P, Dou S X, Wang P Y 2005 Biophysical Chemistry 122 90
[8] Bahloul A, Chevreux G, Wells A L, Martin D, Nolt J, Yang Z H, Chen L Q, Potier N, Dorsselaer A V, Rosenfeld S, Houdusse H, Sweeney H L 2004 PNAS 101 4787
[9] Hasson T, Mooseker E M 1994 Journal of Cell Biology 127 425
[10] Ménétrey J, Bahloul A, Wells A L, Yengo C M, Morris C A, Sweeney H L, Houdusse A 2005 Nature 435 779
[11] Park H, Li A, Chen L Q, Houdusse A, Selvin P R, Sweeney H L 2007 PNAS 104 778
[12] Altman D, Sweeney H L, Spudich J A 2004 Cell 116 737
[13] De La Cruz E M, Ostap E M, Sweeney H L 2001 Journal of Biological Chemistry 276 32373
[14] Reifenberger J G, Toprak E, Kim H J, Safer D, Sweeney H L, Selvin P R 2009 PNAS 106 18255
[15] Bao J D, Zhuo Y Z 1998 Chinese Science Bulletin 43 1493
[16] Bao J D 1997 Chinese Journal of Computational Physics 14 463 (in Chinese) [包景东 1997 计算物理 14 463]
[17] Marchesoni F 1997 Physical Review E 56 2497
[18] Guo C, Yin Y H 2010 Chinese Science Bulletin 55 2675 (in Chinese) [郭朝, 殷跃红 2010 科学通报 55 2675]
[19] Kolomeisky A B, Fisher M E 2003 Biophysical Journal 84 1642
[20] Xu W, Zhang X Y 2007 Chin. Phys. 16 928
[21] Wang H Y, Bao J D 2010 Physica A 389 433
[22] Li F Z, Su W F, Hu K H 2009 Acta Biophysica Sinica 25 133 (in Chinese) [李防震, 苏万芳, 胡匡祜 2009 生物 25 133]
[23] Feng J, Zhuo Y Z 2005 Chin. Phys. Lett. 22 503
[24] Chen Z X 2003 Computational physics (Vol. 2) (Harbin: Harbin Institute of Technology Press) p92 (in Chinese) [陈锺贤 2003 计算物理学(第二版)(哈尔滨: 哈尔滨工业大学出版社)第92页]
[25] Bao J D 2009 Stochastic simulation method of classical and quantum dissipative systems (BeiJing: Science Press) p113 (in Chinese) [包景东 2009 经典和量子耗散系统的随机模拟方法(北京: 科学出版社)第113页]
[26] Spudich J A, Sivaramakrishnan S 2010 Nature Reviews Molecular Cell Biology 11 128
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