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Scattered light by the sample is usually one of the main error source in conventional transmission spectroscopy and diffuse reflection spectroscopy. However, scattered light may be useful for photoacoustic spectroscopy measurement. In the present experiment, the photoacoustic spectra of an olanzapine drug tablet and its powder are studied. The olanzapine tablet is a weakly light-absorbing solid mixture and its main constituent is olanzapine. In order to eliminate the background signal produced by the photoacoustic cell wall due to absorbing the scattered light by the sample, the difference between the photoacoustic spectrum of the sample and that of its base is taken and normalized with the photoacoustic spectrum of carbon black. It is found that the photoacoustic spectroscopic signatures of olanzapine in the olanzapine table become obvious when the olanzapine table is powdered. This is the result of the internal light scattering effect in the sample. The scattered light which serves as an obstacle in conventional optical spectroscopy techniques, however, facilitates the photoacoustic spectroscopy measurement. This indicates the particular advantage of photoacoustic spectroscopy. A new method to preliminarily fast identify the main absorbing component in a weakly light-absorbing solid mixture is proposed based on the above experiment. This method can be applied to the field of solid drug and mineral and soil and so on.
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Keywords:
- photoacoustic spectroscopy /
- scattered light /
- weakly light-absorbing solid mixture /
- olanzapine
[1] Rosencwaig A, Gersho A 1976 J. Appl. Phys. 47 64
[2] Rosencwaig A 1975 Anal. Chem. 47 592
[3] Rosencwaig A 1980 Photoacoustic and Photoacoustic Spectroscopy (New York:Wiley)
[4] West G A 1983 Rev. Sci. Instrum. 54 797
[5] Tam A 1986 Rev. Mod. Phys. 58 381
[6] Haisch C 2011 Meas. Sci. Technol. 23 012001
[7] Lee K H, Li Y D, Du Y L, Wu B M 2003 Acta Phys. Sin. 52 1260 (in Chinese) [李纪焕, 李宜德, 杜英磊, 吴柏枚 2003 52 1260]
[8] Wang H Y, Yang Y T, Liu X J, Zhang S Y 2010 J. Rare Earth 28 211
[9] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5845 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5845]
[10] Helander P, Lundstrom I, McQueen D 1980 J. Appl. Phys. 51 3841
[11] Tilgner R 1981 Appl. Opt. 20 3780
[12] Burggraf L W, Leyden D E 1981 Anal. Chem. 53 759
[13] Becconsall J K, Percy J, Reid R F 1981 Anal. Chem. 53 2037
[14] Rajian J R, Carson P L, Wang X 2009 Opt. Express 17 4879
[15] McClelland J F, Kniseley R N 1976 Appl. Opt. 15 2967
[16] Foldy L L 1945 Phys. Rev. 67 107
[17] Lax M 1951 Rev. Mod. Phys. 23 287
[18] Twersky V 1970 J. Opt. Soc. Am. 60 1084
[19] Yip W, Li X 2008 Opt. Lett. 33 2877
[20] Fisher A R, Schissler A J, Schotland J C 2007 Phys. Rev. E 76 036604
[21] Helander P 1983 J. Appl. Phys. 54 3410
[22] McClelland J F, Kniseley R N 1976 Appl. Opt. 15 2658
[23] Mironychev A P, Maksimova I L, Romanov S V 1998 Proc. SPIE BIOS Europe'97 3354 383
[24] Kawahara T, Yamaguchi N, Mihara M, Kiyotoo T, Kimura A, Funaki S, Morimoto J, Tahira K, Miyakawa T 2000 Mem. Nat. Def. Acad. Math. Phys. Chem. Eng. 40 31
[25] Rajesh R J, Carson P L, Wang X D 2009 Porc. SPIE p717715
[26] Stefansson S E 2009 U.S. Patent 0035332 [2009-02-05]
[27] Rosencwaig A 1977 Rev. Sci. Instrum. 48 1133
[28] Raggi M A, Casamenti G, Mandrioli R, Izzo G, Kenndler E 2000 J. Pharmaceu. Biomed. 23 973
[29] Ayala A, Siesler H, Boese R, Hoffmann G, Polla G, Vega D 2006 Int. J. Pharm. 326 69
[30] Reich G 2005 Adv. Drug Deliver. Rev. 57 1109
[31] Roggo Y, Chalus P, Maurer L, Lema-Martinez C, Edmond A, Jent N 2007 J. Pharmaceut. Biomed. 44 683
[32] Nakai Y, Yamamoto K, Terada K, Sakai M 1985 Chem. Pharm. Bull. 33 3068
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[1] Rosencwaig A, Gersho A 1976 J. Appl. Phys. 47 64
[2] Rosencwaig A 1975 Anal. Chem. 47 592
[3] Rosencwaig A 1980 Photoacoustic and Photoacoustic Spectroscopy (New York:Wiley)
[4] West G A 1983 Rev. Sci. Instrum. 54 797
[5] Tam A 1986 Rev. Mod. Phys. 58 381
[6] Haisch C 2011 Meas. Sci. Technol. 23 012001
[7] Lee K H, Li Y D, Du Y L, Wu B M 2003 Acta Phys. Sin. 52 1260 (in Chinese) [李纪焕, 李宜德, 杜英磊, 吴柏枚 2003 52 1260]
[8] Wang H Y, Yang Y T, Liu X J, Zhang S Y 2010 J. Rare Earth 28 211
[9] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5845 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5845]
[10] Helander P, Lundstrom I, McQueen D 1980 J. Appl. Phys. 51 3841
[11] Tilgner R 1981 Appl. Opt. 20 3780
[12] Burggraf L W, Leyden D E 1981 Anal. Chem. 53 759
[13] Becconsall J K, Percy J, Reid R F 1981 Anal. Chem. 53 2037
[14] Rajian J R, Carson P L, Wang X 2009 Opt. Express 17 4879
[15] McClelland J F, Kniseley R N 1976 Appl. Opt. 15 2967
[16] Foldy L L 1945 Phys. Rev. 67 107
[17] Lax M 1951 Rev. Mod. Phys. 23 287
[18] Twersky V 1970 J. Opt. Soc. Am. 60 1084
[19] Yip W, Li X 2008 Opt. Lett. 33 2877
[20] Fisher A R, Schissler A J, Schotland J C 2007 Phys. Rev. E 76 036604
[21] Helander P 1983 J. Appl. Phys. 54 3410
[22] McClelland J F, Kniseley R N 1976 Appl. Opt. 15 2658
[23] Mironychev A P, Maksimova I L, Romanov S V 1998 Proc. SPIE BIOS Europe'97 3354 383
[24] Kawahara T, Yamaguchi N, Mihara M, Kiyotoo T, Kimura A, Funaki S, Morimoto J, Tahira K, Miyakawa T 2000 Mem. Nat. Def. Acad. Math. Phys. Chem. Eng. 40 31
[25] Rajesh R J, Carson P L, Wang X D 2009 Porc. SPIE p717715
[26] Stefansson S E 2009 U.S. Patent 0035332 [2009-02-05]
[27] Rosencwaig A 1977 Rev. Sci. Instrum. 48 1133
[28] Raggi M A, Casamenti G, Mandrioli R, Izzo G, Kenndler E 2000 J. Pharmaceu. Biomed. 23 973
[29] Ayala A, Siesler H, Boese R, Hoffmann G, Polla G, Vega D 2006 Int. J. Pharm. 326 69
[30] Reich G 2005 Adv. Drug Deliver. Rev. 57 1109
[31] Roggo Y, Chalus P, Maurer L, Lema-Martinez C, Edmond A, Jent N 2007 J. Pharmaceut. Biomed. 44 683
[32] Nakai Y, Yamamoto K, Terada K, Sakai M 1985 Chem. Pharm. Bull. 33 3068
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