Synchronization between FitzHugh-Nagumo neurons coupled with phototube

Zhang Xiu-Fang; Ma Jun; Xu Ying; Ren Guo-Dong

doi:10.7498/aps.70.20201953

Abstract

The photoreceptors can receive all kinds of visible light which is translated to the bioelectrical signal for the visual cortex. The function would be simulated by the photoelectric effect. This paper studies the dynamic characteristics of FitzHugh-Nagumo neurons coupled with a phototube. In the parameter space of phototube, the synchronization region of the coupled system in which the neuron mode is in chaos and burst, is discussed in detail; the data show that the forced resonance is prominent in the complete synchronization of the system when the coupling strength is low, while the phase synchronization is observed in numerical experiment when the coupling strength is strong. The active operation of the phototube, as well the inverse cutoff voltage can modulate the synchronization of the system. Our work can be used to understand the mechanism of the retinal diseases, such as macular degeneration.

Keywords:

Authors and contacts

1.
Department of Physics, Lanzhou University of Technology, Lanzhou 730050, China
2.
School of Mathematics and Statistics, Shandong Normal University, Ji’nan 250014, China

Corresponding author: Ren Guo-Dong, rengd@lut.edu.cn

Funds: Project supported by the National Natural Science Foundation of China (Grant Nos. 11672122, 12062009) and the Natural Science Foundation of Gansu Province, China (Grant No. 20JR5RA473)

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References

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[2]	Iqbal M, Rehan M, Hong K S 2017 Plos One 12 e0176986 Google Scholar
[3]	Sotero R C, Trujillo-Barreto N J 2008 Neuroimage 39 290 Google Scholar
[4]	Izhikevich E M 2004 IEEE Trans. Neural Networks 15 1063 Google Scholar
[5]	Ibarz B, Casado J M, Sanjuán M A F 2011 Phys. Rep. 501 1 Google Scholar
[6]	Hodgkin A L, Huxley A F 1990 Bull. Math. Biol. 52 25 Google Scholar
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[11]	Pikovskii A, Rabinovich M 1978 Dokl. Akad. Nauk SSSR 239 301
[12]	Lv M, Wang C, Ren G, Ma J, Song X 2016 Nonlinear Dyn. 85 1479 Google Scholar
[13]	Baines P G 2008 Prog. Phys. Geogr. 32 475 Google Scholar
[14]	Zhang X, Wang C, Ma J, Ren G 2020 Mod. Phys. Lett. B 2050267 Google Scholar
[15]	Zhang G, Ma J, Alsaedi A, Ahmad B, Alzahrani F 2018 Appl. Math. Comput. 321 290 Google Scholar
[16]	Yao Z, Ma J, Yao Y, Wang C 2019 Nonlinear Dyn. 96 205 Google Scholar
[17]	Xu Y M, Yao Z, Hobiny A, Ma J 2019 Front. Inform. Tech. El. 20 571 Google Scholar
[18]	Liu Z, Wang C, Jin W, Ma J 2019 Nonlinear Dyn. 97 2661 Google Scholar
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[24]	Li J R, Wang J P, Jiang L 1994 Biosens. Bioelectron. 9 147 Google Scholar
[25]	Zou W, Senthilkumar D V, Zhan M, Kurths J 2013 Phys. Rev. Lett. 111 014101 Google Scholar
[26]	Wu Y, Xiao J, Hu G, Zhan M 2012 EPL 97 40005 Google Scholar
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Cited By

图 1 FHN神经元的等效电路图

Figure 1. Equivalent circuit diagram of FHN neuron.

DownLoad: Full-Size Img PowerPoint

图 2 光电管的电流-电压特性

Figure 2. I-V characteristics of phototube.

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图 3 光电管耦合FHN神经元系统的等效电路图

Figure 3. Equivalent circuit diagram of the coupled FHN neuron system.

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图 4 单个FHN神经元在不同参数下的ISI　(a) b = 0.8, c = 0.1; (b) a = 0.7, c = 0.1; (c) a = 0.7, b = 0.8

Figure 4. ISI of single FHN neuron with different parameters: (a) b = 0.8, c = 0.1; (b) a = 0.7, c = 0.1; (c) a = 0.7, b = 0.8.

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图 5 耦合系统中神经元的ISI和放电序列(f = 0.16)　(a) u_a = 0.1; (b) I₀ = 1.5, u_a = 0.1; (c) I₀ = 2.5, u_a = 0.1; (d) I₀ = 0.3; (e) u_a = 1.5, I₀ = 0.3; (f) u_a = 2.3, I₀ = 0.3

Figure 5. ISI and the firing sequence of neuron in the coupled system (f = 0.16): (a) u_a = 0.1; (b) I₀ = 1.5, u_a = 0.1; (c) I₀ = 2.5, u_a = 0.1; (d) I₀ = 0.3; (e) u_a = 1.5, I₀ = 0.3; (f) u_a = 2.5, I₀ = 0.3.

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图 6 u_a和I₀的参数空间中, 耦合系统(case 1)的同步区间　(a)最大误差函数θ_max; (b)最大相位差∆ϕ_max

Figure 6. Synchronization region of the coupled system (case 1) in the parameter space of u_a vs. I₀: (a) Maximum error function θ_max; (b) maximum phase difference ∆ϕ_max.

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图 7 误差函数、相位差和功率随时间的演化(u_a = 0.1)　(a), (e), (i) I₀ = 0.01; (b), (f), (j) I₀ = 0.2; (c), (g), (k) I₀ = 0.8; (d), (h), (l) I₀ = 1

Figure 7. Evolution of error function, phase difference and power (u_a = 0.1): (a), (e), (i) I₀ = 0.01; (b), (f), (j) I₀ = 0.2; (c), (g), (k) I₀ = 0.8; (d), (h), (l) I₀ = 1.

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图 8 系统误差与相位差随时间的演化(u_a = 0.5)　(a), (e) I₀ = 0.01; (b), (f) I₀ = 0.2; (c), (g) I₀ = 0.8; (d), (h) I₀ = 1

Figure 8. Evolution of error function and phase error (u_a = 0.5): (a), (e) I₀ = 0.01; (b), (f) I₀ = 0.2; (c), (g) I₀ = 0.8; (d), (h) I₀ = 1.

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图 9 耦合系统中神经元的ISI和放电序列(f = 0.002)　(a) u_a = 0.01; (b) I₀ = 0.5, u_a = 0.01; (c) I₀ = 1.5, u_a = 0.01; (d) I₀ = 0.3; (e) u_a = 0.5, I₀ = 0.3; (f) u_a = 1.5, I₀ = 0.3

Figure 9. ISI and the firing sequence of neuron in the coupled system (f = 0.002): (a) u_a = 0.01; (b) I₀ = 0.5, u_a = 0.1; (c) I₀ = 1.5, u_a = 0.1; (d) I₀ = 0.3; (e) u_a = 0.5, I₀ = 0.3; (f) u_a = 1.5, I₀ = 0.3.

DownLoad: Full-Size Img PowerPoint

图 10 u_a和I₀的参数空间中, 耦合系统(case 3)的同步区间　(a)最大误差函数θ_max; (b)最大相位差∆ϕ_max

Figure 10. Synchronization region of the coupled system (case 3) in the parameter space of u_a vs. I₀: (a) Maximum error function θ_max; (b) maximum phase difference ∆ϕ_max.

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图 11 最大误差函数和最大相位差随参数的变化(灰色曲线为(6)式中的非线性耦合, 红色曲线为线性耦合)　(a), (b) u_a = 0.01; (c), (d) I₀ = 0.001

Figure 11. The maximum error function and the maximum phase difference change with the parameters, the grey curve represents the nonlinear coupling in Eq. (6) and the red curve is the linear one: (a), (b) u_a = 0.01; (c), (d) I₀ = 0.001.

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图 12 系统误差、相位差和光电管功率随时间的演化(u_a = 0.01)　(a), (e), (i) I₀ = 0.001; (b), (f), (j) I₀ = 0.01; (c), (g), (k) I₀ = 0.013; (d), (h), (l) I₀ = 0.014

Figure 12. Evolution of error function, phase error and phototube power (u_a = 0.01): (a), (e), (i) I₀ = 0.001; (b), (f), (j) I₀ = 0.01; (c), (g), (k) I₀ = 0.013; (d), (h), (l) I₀ = 0.014.

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图 13 系统误差与相位差随时间的演化(u_a = 0.5)　(a), (e) I₀ = 0.001; (b), (f) I₀ = 0.01; (c), (g) I₀ = 0.013; (d), (h) I₀ = 0.014

Figure 13. Evolution of error function and phase error for variables (u_a = 0.5): (a), (e) I₀ = 0.001; (b), (f) I₀ = 0.01; (c), (g) I₀ = 0.013; (d), (h) I₀ = 0.014.

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表 1 不同外界刺激频率下的耦合FHN神经元分类

Table 1. Category of the coupled FHN neurons driven by external stimulation with different frequencies.

频率f 0.16 0.002 0.012 0.06

放电状态混沌放电簇放电尖峰放电周期放电
反向截止电压u_a 0.1 0.5 0.01 0.5 0.01 0.5 0.01 0.5

耦合分类 case 1 case 2 case 3 case 4 case 5 case 6 case 7 case 8

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[1]	Ma J, Song X, Jin W, Wang C 2015 Chaos, Solitons Fractals 80 31 Google Scholar
[2]	Iqbal M, Rehan M, Hong K S 2017 Plos One 12 e0176986 Google Scholar
[3]	Sotero R C, Trujillo-Barreto N J 2008 Neuroimage 39 290 Google Scholar
[4]	Izhikevich E M 2004 IEEE Trans. Neural Networks 15 1063 Google Scholar
[5]	Ibarz B, Casado J M, Sanjuán M A F 2011 Phys. Rep. 501 1 Google Scholar
[6]	Hodgkin A L, Huxley A F 1990 Bull. Math. Biol. 52 25 Google Scholar
[7]	Fitzhugh R 1961 Biophys. J. 1 445 Google Scholar
[8]	Shilnikov A 2012 Nonlinear Dyn. 68 305 Google Scholar
[9]	Miesenbock G, Kevrekidis I G 2005 Annu. Rev. Neurosci. 28 533 Google Scholar
[10]	Gu H, Pan B 2015 Nonlinear Dyn. 81 2107 Google Scholar
[11]	Pikovskii A, Rabinovich M 1978 Dokl. Akad. Nauk SSSR 239 301
[12]	Lv M, Wang C, Ren G, Ma J, Song X 2016 Nonlinear Dyn. 85 1479 Google Scholar
[13]	Baines P G 2008 Prog. Phys. Geogr. 32 475 Google Scholar
[14]	Zhang X, Wang C, Ma J, Ren G 2020 Mod. Phys. Lett. B 2050267 Google Scholar
[15]	Zhang G, Ma J, Alsaedi A, Ahmad B, Alzahrani F 2018 Appl. Math. Comput. 321 290 Google Scholar
[16]	Yao Z, Ma J, Yao Y, Wang C 2019 Nonlinear Dyn. 96 205 Google Scholar
[17]	Xu Y M, Yao Z, Hobiny A, Ma J 2019 Front. Inform. Tech. El. 20 571 Google Scholar
[18]	Liu Z, Wang C, Jin W, Ma J 2019 Nonlinear Dyn. 97 2661 Google Scholar
[19]	Tosini G, Doyle S, Geusz M, Menaker M 2000 Proc. Natl. Acad. Sci. 97 11540 Google Scholar
[20]	Menaker M 1972 Sci. Am. 226 22 Google Scholar
[21]	Kennedy D 1958 Am. J. Ophthal. 46 19 Google Scholar
[22]	Martenson M E, Halawa O I, Tonsfeldt K J, et al. 2016 Pain 157 868 Google Scholar
[23]	Liu Y, Xu W J, Ma J, Alzahrani F, Hobiny A 2020 Front. Inform. Tech. El. 21 1387 Google Scholar
[24]	Li J R, Wang J P, Jiang L 1994 Biosens. Bioelectron. 9 147 Google Scholar
[25]	Zou W, Senthilkumar D V, Zhan M, Kurths J 2013 Phys. Rev. Lett. 111 014101 Google Scholar
[26]	Wu Y, Xiao J, Hu G, Zhan M 2012 EPL 97 40005 Google Scholar
[27]	Perc M 2009 Biophys. Chem. 141 175 Google Scholar
[28]	Lin W, Wang Y, Ying H, Lai Y C, Wang X 2015 Phys. Rev. E 92 012912 Google Scholar
[29]	张平伟, 唐国宁, 罗晓曙 2005 54 3497 Google Scholar Zhang P W, Tang G N, Luo X S 2005 Acta Phys. Sin. 54 3497 Google Scholar
[30]	Wouapi K M, Fotsin B H, Louodop F P, Feudjio K F, Njitacke Z T, Djeudjo T H 2020 Cogn. Neurodyn. 14 375 Google Scholar
[31]	Shafiei M, Jafari S, Parastesh F, Ozer M, Kapitaniak T, Perc M 2020 Commun. Nonlinear Sci. Numer. Simul. 84 105175 Google Scholar
[32]	Phan C, You Y 2020 Nonlinear. Anal.-Real 55 103139 Google Scholar
[33]	Moayeri M M, Rad J A, Parand K 2020 Comput. Math. Appl. 80 1887 Google Scholar
[34]	Makovkin S Y, Shkerin I V, Gordleeva S Y, Ivanchenko M V 2020 Chaos, Solitons Fractals 138 109951 Google Scholar
[35]	Zou Y L, Zhu J, Chen G, Luo X S 2005 Chaos, Solitons Fractals 25 1245 Google Scholar
[36]	Zhou S, Hong Y, Yang Y, Lü L, Li C 2020 Pramana J. Phys. 94 34 Google Scholar
[37]	Venkatesh P, Venkatesan A, Lakshmanan M 2016 Pramana J. Phys. 86 1195 Google Scholar
[38]	Sivaganesh G, Sweetlin M D, Arulgnanam A 2016 J. Korean Phys. Soc. 69 124 Google Scholar
[39]	Binczak S, Jacquir S, Bilbault J M, Kazantsev V B, Nekorkin V I 2006 Neural Networks 19 684 Google Scholar
[40]	Wade J J, Mcdaid L J, Harkin J, Crunelli V, Kelso J S 2011 PloS One 6 e29445 Google Scholar
[41]	Sambas A, WS M S, Mamat M 2015 J. Eng. Sci. Tech. Rev. 8 89 Google Scholar
[42]	Daoudal G, Hanada Y, Debanne D 2002 PNAS 99 14512 Google Scholar
[43]	Chorev E, Brecht M 2012 J. Neurophysiol. 108 1584 Google Scholar
[44]	杨永霞, 李玉叶, 古光华 2020 69 040501 Google Scholar Yhang Y X, Li Y Y, Gu G H 2020 Acta Phys. Sin. 69 040501 Google Scholar
[45]	汪芃, 李倩昀, 唐国宁 2018 67 030502 Google Scholar Wang P, Li Q Y, Tang G N 2018 Acta Phys. Sin. 67 030502 Google Scholar
[46]	FitzHugh R 1955 Bull. Math. Biophys. 17 257 Google Scholar
[47]	Nagumo J, Arimoto S, Yoshizawa S 1962 Proc. IRE 50 2061 Google Scholar
[48]	Kawato M, Suzuki R 1980 J. Theor. Biol. 86 547 Google Scholar
[49]	Okuda M 1981 Prog. Theor. Phys. 66 90 Google Scholar
[50]	Treutlein H, Schulten K 1985 Ber. Bunse. Ges. Phys. Chem. 89 710 Google Scholar
[51]	Rajasekar S, Lakshmanan M 1988 J. Theor. Biol. 133 473 Google Scholar
[52]	Einstein A 1905 Ann. Physik. 17 132

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