利用纳米力学方法对皮肤进行超声组织定征的研究

欧阳灵; 刘晓宙; 刘杰惠; 龚秀芬

doi:10.7498/aps.63.104304

摘要

纳米力学方法适用于具有离散特性的材料. 利用纳米力学方法，得出声波在多层皮肤组织中的波动方程. 分别改变黑素瘤皮肤的泊松比、黑素瘤侵袭厚度（Breslow深度）、节间距离，计算多层皮肤结构模型对垂直入射纵声波的反射系数. 同时计算了声速和声衰减系数随组织参数的变化. 计算结果表明，可综合利用一定频率段内反射系数最小点数、声速和衰减系数的变化来表征正常皮肤和病变皮肤.

关键词:

Doublet mechanics (DM) is applied to materials with dispersing property. The wave equation in multi-layered skin tissue is obtained through the method of DM in this article. By changing the Poisson ratio in melanoma skin tissue, the growth and spread of melanoma (Breslow thickness), the internode distance, the reflection coefficients of the longitudinal waves incident vertically in the multi-layered skin model are calculated. And the acoustic velocity and acoustic attenuation coefficient changing with tissue parameters are also calculated. The results show that we can synthesize the change of the number of the minimal reflection coefficient, acoustic velocity and attenuation coefficient to discriminate cancerous skin from normal skin within a certain frequency.

Keywords:

作者及机构信息

1.
南京大学声学研究所, 近代声学教育部重点实验室, 南京 210093

基金项目: 国家重点基础研究发展计划（批准号：2012CB921504，2011CB707902）、国家自然科学基金（批准号：11274166）、声场声信息国家重点实验室基金（批准号：SKLA201207）和中央高等学校基本科研基金（批准号：1113020403，1101020402）资助的课题.

Authors and contacts

1.
Key Laboratory of Modern Acoustics of Ministry of Education, Institute of Acoustics, Nanjing University, Nanjing 210093, China

Funds: Project supported by the State Key Development Program for Basic Research of China (Grant Nos. 2012CB921504, 2011CB707902), the National Natural Science Foundation of China (Grant No. 11274166), the Foundation of State Key Laboratory of Acoustics, China (Grant No. SKLA201207), the Fundamental Scientific Research Foundation for the Central Universities of China (Grant Nos. 1113020403, 1101020402).

参考文献

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[2]	Odland G F 1991 Physiology, Biochemistry, and Molecular Biology of the Skin (New York: Oxford University Press) pp3-62
[3]	Jemal A, Siegel R, Xu J, Ward E 2010 CA Cancer J. Clin. 60 277
[4]	Raveh Tilleman T, Tilleman M, Neumann H 2004 Optimization of Incisions in Cutaneous Surgery Including Mohs' Micrographic Surgery (Rotterdam: Erasmus University Rotterdam) p105
[5]	Robins S, Cotran R, Kumar V 1979 Pathologic Basis of Disease (Philadelphia: WB Saunders Company) p1333
[6]	Ferrari M 1997 Advances in Doublet Mechanics (Berlin: Springer) p214
[7]	Liu J, Ferrari M 2002 Dis Markers 18 175
[8]	Liu J, Ferrari M, Rokhlin S I, Sedmak D D 2004 U.S. Patent 20040064050
[9]	Wu J R, Layman C 2004 J. Acoust. Soc. Am. 115 893
[10]	Layman C, Wu J R 2004 J. Acoust. Soc. Am. 116 1244
[11]	Jin Y F, Zhang J, Fang J, Ferrari M 2004 Chin. Phys. Lett. 21 1562
[12]	Jin Y F, Xiong C Y, Fang J, Ferrari M 2009 Chin. Phys. Lett. 26 084601
[13]	Kojic M, Vlastelica I, Decuzzi P, Grank V T, Ferrrari M 2011 Comput. Methods Appl. M. 200 1446
[14]	Ferrari M 2000 Biomed. Microdevices 2 273
[15]	Jiang X, Liu X Z, W J R 2009 Chin. Phys. Lett. 26 074301
[16]	Jiang X, Liu X Z, Gong X F, Zhang F, Wu R R 2011 J. Acoust. Soc. Am. 130 4117
[17]	Jiang X, Liu X Z 2009 Tech. Acoust. 28(Pt.3) 73 (in Chinese) [江鑫, 刘晓宙 2009 声学技术 28(Pt.3) 73]
[18]	Xue H H, Liu X Z, Gong X F, Zhang D 2005 Acta Phys. Sin. 54 5233 (in Chinese)[薛洪惠, 刘晓宙, 龚秀芬, 章东 2005 54 5233]
[19]	Li J L, Liu X Z, Gong X F 2006 Acta Phys. Sin. 55 2809 (in Chinese)[李俊伦, 刘晓宙, 龚秀芬 2006 55 2809]
[20]	Gentile F, Sakamoto J, Righetti R, Decuzzi P, Ferrrari M 2011 J. Biomed. Sci. Eng. 4 362
[21]	Sakamoto J, Decuzzi P, Gentile F, Rokhlin S I, Wang L 2006 BioMEMS and Biomedical Nanotechnology (New York: Springer) pp461-504
[22]	Sakamoto J H 2005 Ph. D. Dissertation (Columbus: Ohio State University)
[23]	Lee R C, Dougherty W 2003 IEEE Trans. Dielectr. Electr. Insul. 10 810

施引文献

[1]	Manschot J F M 1985 Ph. D. Dissertation (Nijmegen: Katholieke University)
[2]	Odland G F 1991 Physiology, Biochemistry, and Molecular Biology of the Skin (New York: Oxford University Press) pp3-62
[3]	Jemal A, Siegel R, Xu J, Ward E 2010 CA Cancer J. Clin. 60 277
[4]	Raveh Tilleman T, Tilleman M, Neumann H 2004 Optimization of Incisions in Cutaneous Surgery Including Mohs' Micrographic Surgery (Rotterdam: Erasmus University Rotterdam) p105
[5]	Robins S, Cotran R, Kumar V 1979 Pathologic Basis of Disease (Philadelphia: WB Saunders Company) p1333
[6]	Ferrari M 1997 Advances in Doublet Mechanics (Berlin: Springer) p214
[7]	Liu J, Ferrari M 2002 Dis Markers 18 175
[8]	Liu J, Ferrari M, Rokhlin S I, Sedmak D D 2004 U.S. Patent 20040064050
[9]	Wu J R, Layman C 2004 J. Acoust. Soc. Am. 115 893
[10]	Layman C, Wu J R 2004 J. Acoust. Soc. Am. 116 1244
[11]	Jin Y F, Zhang J, Fang J, Ferrari M 2004 Chin. Phys. Lett. 21 1562
[12]	Jin Y F, Xiong C Y, Fang J, Ferrari M 2009 Chin. Phys. Lett. 26 084601
[13]	Kojic M, Vlastelica I, Decuzzi P, Grank V T, Ferrrari M 2011 Comput. Methods Appl. M. 200 1446
[14]	Ferrari M 2000 Biomed. Microdevices 2 273
[15]	Jiang X, Liu X Z, W J R 2009 Chin. Phys. Lett. 26 074301
[16]	Jiang X, Liu X Z, Gong X F, Zhang F, Wu R R 2011 J. Acoust. Soc. Am. 130 4117
[17]	Jiang X, Liu X Z 2009 Tech. Acoust. 28(Pt.3) 73 (in Chinese) [江鑫, 刘晓宙 2009 声学技术 28(Pt.3) 73]
[18]	Xue H H, Liu X Z, Gong X F, Zhang D 2005 Acta Phys. Sin. 54 5233 (in Chinese)[薛洪惠, 刘晓宙, 龚秀芬, 章东 2005 54 5233]
[19]	Li J L, Liu X Z, Gong X F 2006 Acta Phys. Sin. 55 2809 (in Chinese)[李俊伦, 刘晓宙, 龚秀芬 2006 55 2809]
[20]	Gentile F, Sakamoto J, Righetti R, Decuzzi P, Ferrrari M 2011 J. Biomed. Sci. Eng. 4 362
[21]	Sakamoto J, Decuzzi P, Gentile F, Rokhlin S I, Wang L 2006 BioMEMS and Biomedical Nanotechnology (New York: Springer) pp461-504
[22]	Sakamoto J H 2005 Ph. D. Dissertation (Columbus: Ohio State University)
[23]	Lee R C, Dougherty W 2003 IEEE Trans. Dielectr. Electr. Insul. 10 810

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