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Spherical cavity transducer can generate high acoustic pressure in a narrow focal region at a sub-wavelength level, which suggests a great potential application in high intensity focused ultrasound (HIFU) treatment. In this paper, tissue lesion induced by a spherical cavity transducer is investigated based on the nonlinear acoustics theory and bio-heat transfer theory. A 430 kHz spherical cavity transducer with a diameter of 240 mm is used to generate tissue lesion for liver tissues. The result shows that the tissue lesion with a size less than a wavelength can be formed under the 2 s HIFU exposure at a acoustic pressure of 53 kPa. The numerical simulations coincide well with the experimental measurements, and the optimization of the design of the spherical cavity transducer is also discussed. This work demonstrates that the spherical cavity transducer can be used in the accurate HIFU tumor treatment.
[1] Sun J M, Yu J, Guo X S, Zhang D 2013 Acta Phys. Sin. 62 054301 (in Chinese) [孙健明, 于洁, 郭霞生, 章东 2013 62 054301]
[2] Xu F, Lu M Z, Wan M X, Fang F 2010 Acta Phys. Sin. 59 1349 (in Chinese) [徐丰, 陆明珠, 万明习, 方飞 2010 59 1349]
[3] Fan T B, Liu Z B, Chen T, Li F Q, Zhang D 2011 Med. Phys. 38 5033
[4] Lu M Z, Wan M X, Shi Y, Song Y C 2001 Acta Phys. Sin. 51 928 (in Chinese) [陆明珠, 万明习, 施雨, 宋延淳 2001 51 928]
[5] Wu F, Wang Z B, Chen W Z, Zou J Z, Bai J, Zhu H, Li K Q, Jin C B, Xie F L, Su H B 2005 Radiology 235 659
[6] Sukhovich A, Merheb B, Muralidharan K, Vasseur J O, Pennec Y, Deymier P A, Page J H 2009 Phys. Rev. Lett. 102 154301
[7] Zhu J, Jung J, Martin-Moreno L, Yin X, Fok L, Zhang X, Garcia-Vidal F J 2011 Nat. Phys. 7 52
[8] Wu F, Wan H, Yuan Y S, Wan W 2006 Chinese Patent 101140354 B [2006-09-04]
[9] Westervelt P J 1963 J. Acoust. Soc. Am. 35 535
[10] Pennes H H 1948 J. Appl. Phycol. 1 93
[11] Sapareto S A, Dewwy W C 1984 Int. J. Radiat. Oncol. 10 787
[12] McDannold N J, King R L, Jolesz F A, Hynynen K H 2000 Radiology 216 517
[13] Hallaj I M, Cleveland R O 1999 J. Acoust. Soc. Am. 105 L7
[14] Mur G 1981 IEEE Trans. Electr. Comp. EMC-23 377
[15] Fan T B, Liu Z B, Zhang D 2013 IEEE Trans. Biomed. Eng. 60 763
[16] Williams R, Cherin E, Lam T Y J, Tavakkoli J, Zemp R J, Foster F S 2006 Phys. Med. Biol. 51 5809
[17] Li Y, Chen Q, Zagzebski J 2004 IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 51 146
[18] Duck F A 1990 Physical Properties of Tissue (New York: Academic Press) p402
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[1] Sun J M, Yu J, Guo X S, Zhang D 2013 Acta Phys. Sin. 62 054301 (in Chinese) [孙健明, 于洁, 郭霞生, 章东 2013 62 054301]
[2] Xu F, Lu M Z, Wan M X, Fang F 2010 Acta Phys. Sin. 59 1349 (in Chinese) [徐丰, 陆明珠, 万明习, 方飞 2010 59 1349]
[3] Fan T B, Liu Z B, Chen T, Li F Q, Zhang D 2011 Med. Phys. 38 5033
[4] Lu M Z, Wan M X, Shi Y, Song Y C 2001 Acta Phys. Sin. 51 928 (in Chinese) [陆明珠, 万明习, 施雨, 宋延淳 2001 51 928]
[5] Wu F, Wang Z B, Chen W Z, Zou J Z, Bai J, Zhu H, Li K Q, Jin C B, Xie F L, Su H B 2005 Radiology 235 659
[6] Sukhovich A, Merheb B, Muralidharan K, Vasseur J O, Pennec Y, Deymier P A, Page J H 2009 Phys. Rev. Lett. 102 154301
[7] Zhu J, Jung J, Martin-Moreno L, Yin X, Fok L, Zhang X, Garcia-Vidal F J 2011 Nat. Phys. 7 52
[8] Wu F, Wan H, Yuan Y S, Wan W 2006 Chinese Patent 101140354 B [2006-09-04]
[9] Westervelt P J 1963 J. Acoust. Soc. Am. 35 535
[10] Pennes H H 1948 J. Appl. Phycol. 1 93
[11] Sapareto S A, Dewwy W C 1984 Int. J. Radiat. Oncol. 10 787
[12] McDannold N J, King R L, Jolesz F A, Hynynen K H 2000 Radiology 216 517
[13] Hallaj I M, Cleveland R O 1999 J. Acoust. Soc. Am. 105 L7
[14] Mur G 1981 IEEE Trans. Electr. Comp. EMC-23 377
[15] Fan T B, Liu Z B, Zhang D 2013 IEEE Trans. Biomed. Eng. 60 763
[16] Williams R, Cherin E, Lam T Y J, Tavakkoli J, Zemp R J, Foster F S 2006 Phys. Med. Biol. 51 5809
[17] Li Y, Chen Q, Zagzebski J 2004 IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 51 146
[18] Duck F A 1990 Physical Properties of Tissue (New York: Academic Press) p402
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