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本文利用磁屏蔽室和二阶轴向梯度计抑制环境磁场噪声, 建立了单通道脑磁探测系统, 并对不用声音频率下脑听觉激励磁场N100m响应进行了初步探测.结果显示, 1000 Hz音频和100 ms持续声音激励下, N100m峰值的典型强度约为0.4 pT.在低的声音频率激励下, N100m峰出现延时, 100 Hz 和1000 Hz之间的延时差别达到25 ms.相比于1 kHz特定频率的声音激励, 14 kHz 随机变频下的N100m峰幅度增强, 出现了数毫秒的延时.本研究为下一步利用软件梯度计进行多通道脑磁系统和听觉机理研究奠定了一定的基础.Superconducting quantum interface devices (SQUID) is widely used in human brain signal detection. As one of the applications of magnetoencephalography (MEG) system, the detection of the auditory evoked response is useful for the development of MEG system and the research into auditory mechanism of human brain. Generally, the auditory evoked response includes three peaks which are P50m, N100m and P200m. We develop a single-channel MEG system in a magnetically shielded room based on the superconducting quantum interface device (SQUID) and second-order axial gradiometer. The responses of the main peak N100m under different tone frequencies are preliminarily studied by using our system. The typical evoked response of N100m to 1 kHz pure tone and 100 ms duration is measured to be 0.4 pT. Under the tone stimulus at low frequency, the delay of the peak N100m to the tone onset is 125 ms at 100 Hz, which is longer than the typical value of 100 ms. In comparison with the response to 1 kHz pure tone stimulus, the amplitude of the evoked response in a random frequency range from 1 kHz to 4 kHz is stronger and the delay is several milliseconds. This work lays the foundation of the studies of the auditory mechanism and multichannel MEG system by using software gradiometers.
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Keywords:
- superconducting quantum interface device (SQUID) /
- magnetoencephalography (MEG) /
- gradiometer /
- auditory stimulus
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[8] Richard E F, Roozbeh R, Andrew C P 2009 Phys. Life. Rev. 6 1
[9] Rieger J W, Braun C, Bülthoff H H, Gegenfurtner K R 2005 J. Vision 5 275
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[13] Andrä W, Nowak H 2007 Magnetism in Medicine. 2nd ed. (Weinheim: Wiley-VCH) p117
[14] Hamada T 2006 Biol. Cybem. 94 143
[15] Gage N M, Siegel B, Callen M, Roberts T P L 2003 Neuroreport, 14 2047
[16] Finney E M, Clementz B A, Hickok G, Dobkins K R 2003 Neuroreport, 14 1425
[17] Blumenfeld L D, Clementz B A 2001 Clin. Neurophysiol. 112 1650
[18] Hirano Y, Hirano S, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T 2010 Schizophr. Res. 117 61
[19] Roberts T P L, Khan S Y, Rey M, Monroe J F, Cannon K, Blaskey L, Woldoff S, Qasmieh S, Gandal M, Schmidt G L, Zarnow D M, Levy S E, Edgar J C 2010 Autism Res. 3 8
[20] Li Z, Liu D T, Tian Y, Chen G H, Zhang L H, Yang Q S, Feng J 2007 Chin. Phys. 16 2913
[21] Wang Q, Ma P, Lu H, Tang X Z, Hua N, Tang F K 2009 Chin. Phys. B 18 5566
[22] Zhang Y M, Zhang N, Han Z Z,Wang Y L,Wang C X, Chen H Y, Wang Y J, Zhang X H 2010 Neurol. Res. 32 625
[23] Zhang Y T, Geng Z J, Zhang Q, Li W, Zhang J 2006 Chin. Med. J. 119 1548
[24] Zhang Z Q, Zhang J, Zhao H Y, Zhang P, Lin T, Zeng Y J 2010 Neurosurg. Quart. 20 268
[25] Zhang S L,Wang Y L,Wang HW, Jiang S Q, Xie XM2009 Phys. Med. Biol. 54 4793
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[1] Pizzella V, Penna S D, Gratta C D, Romani G L 2001 Supercond. Sci. Technol. 14 R79
[2] Sternickel K, Braginski A I 2006 Supercond. Sci. Technol. 19 S160
[3] Rampp S, Stefan 2007 Expert Rev. Med. Devices 4 335
[4] Knowlton R C 2003 Curr. Neurol. Neurosci. Rep. 3 341
[5] Stufflebeam S M, Tanaka N, Ahlfors S P 2009 Hum. Brain Mapp. 30 1813
[6] Hämäläinen M, Hari R, Ilmoniemi R J, Knuutila J, Lounasmaa O V 1999 Rev. Mod. Phys. 65 413
[7] Finney E M, Clementz B A, Hickok G, Dobkins K R 2003 Neuroreport 14 1425
[8] Richard E F, Roozbeh R, Andrew C P 2009 Phys. Life. Rev. 6 1
[9] Rieger J W, Braun C, Bülthoff H H, Gegenfurtner K R 2005 J. Vision 5 275
[10] Lounasmma O V, Seppä H 2004 J. Low Temp. Phys. 135 295
[11] Brake H J M, Flokstra J, Jaszczuk W, Stammis R, Ancum G K, Martinez A, Rogalla H 1991 Clin. Phys. Physiol. Meas. 12 45
[12] Lee Y H, Yu K K, Kwon H, Kim J M, Kim K, Park Y K, Yang H C, Chen K L, Yang S Y, Horng H E 2009 Supercond. Sci. Technol. 22 045023
[13] Andrä W, Nowak H 2007 Magnetism in Medicine. 2nd ed. (Weinheim: Wiley-VCH) p117
[14] Hamada T 2006 Biol. Cybem. 94 143
[15] Gage N M, Siegel B, Callen M, Roberts T P L 2003 Neuroreport, 14 2047
[16] Finney E M, Clementz B A, Hickok G, Dobkins K R 2003 Neuroreport, 14 1425
[17] Blumenfeld L D, Clementz B A 2001 Clin. Neurophysiol. 112 1650
[18] Hirano Y, Hirano S, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T 2010 Schizophr. Res. 117 61
[19] Roberts T P L, Khan S Y, Rey M, Monroe J F, Cannon K, Blaskey L, Woldoff S, Qasmieh S, Gandal M, Schmidt G L, Zarnow D M, Levy S E, Edgar J C 2010 Autism Res. 3 8
[20] Li Z, Liu D T, Tian Y, Chen G H, Zhang L H, Yang Q S, Feng J 2007 Chin. Phys. 16 2913
[21] Wang Q, Ma P, Lu H, Tang X Z, Hua N, Tang F K 2009 Chin. Phys. B 18 5566
[22] Zhang Y M, Zhang N, Han Z Z,Wang Y L,Wang C X, Chen H Y, Wang Y J, Zhang X H 2010 Neurol. Res. 32 625
[23] Zhang Y T, Geng Z J, Zhang Q, Li W, Zhang J 2006 Chin. Med. J. 119 1548
[24] Zhang Z Q, Zhang J, Zhao H Y, Zhang P, Lin T, Zeng Y J 2010 Neurosurg. Quart. 20 268
[25] Zhang S L,Wang Y L,Wang HW, Jiang S Q, Xie XM2009 Phys. Med. Biol. 54 4793
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