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光声测温是一种利用光声效应来进行温度监控的新方法，具有非侵入式、高灵敏度和探测深度较深等优点.但现有的单波长光声测温方法极易受到系统及测量环境干扰而导致测量精度降低.为了解决这一问题，本文提出了一种双波长光声温度测量方法.在光声测温理论的基础上，分析推导了双波长光声测温的基本原理，并进行了仿体及离体组织样品的双波长光声测温实验.实验结果显示，与传统单波长模式相比，双波长模式下的光声温度测量误差明显减小，测量精度平均提高35%以上.研究结果表明双波长光声测温方法能够有效提高光声温度测量的精度和稳定性，可作为一种更精准的光声温度监控方法应用于医疗手术等领域.Photoacoustic temperature measurement is a novel technique in which photoacoustic effect is used to measure temperature. It has the advantages of non-invasiveness, high sensitivity and deep penetration depth, which is suitable for monitoring the temperature distribution for the safe deposition of heat energy and efficient destruction of tumor cells during thermotherapy or cryotherapy. However, the present reported methods usually use one single wavelength for photoacoustic temperature measuring and are vulnerable to systematic and environmental influence, including the instability of system caused by fluctuation of laser energy, position displacement of transducer, and tissue complexity, which could reduce the measuring accuracy and stability. To solve this problem, a new photoacoustic temperature measuring method by employing two laser wavelengths is proposed in this paper. Firstly a brief theoretical analysis of dual-wavelengths photoacoustic temperature method is performed based on the linear relationship between photoacoustic signal and tissue temperature under two different wavelengths. Then two different samples including phantom of graphite and ex vivo pig blood are experimented respectively. The experimental temperature is set to be in a range of 26 ℃-48 ℃, which is controlled by a precise hot plate. And for improving the detection accuracy, the dual-wavelengths are selected as 760 and 900 nm for graphite phantom, 820 nm and 860 nm for ex vivo pig blood according to their absorption spectrum repetitively. The obtained results reveal that the temperature measuring correlation coefficients by dual-wavelength method can reach to 0.98 in graphite phantom and 0.99 in ex vivo tissue, respectively. And the average measurement deviation decreases to 0.88 ℃ in dual-wavelength method from 1.31 ℃ for the traditional single wavelength method for graphite phantom. While in ex vivo tissue, the measurement deviation decreases to 0.90 ℃ in dual-wavelength method from the average value 1.45 ℃ for the single wavelength method. Furthermore, the standard deviations of error are respectively reduced by an average of 38% in graphite phantom and an average of 30% in ex vivo tissue, respectively. These results indicate that the dual-wavelength method of photoacoustic temperature measurement can improve both the measuring accuracy and stability, and has a potential to be applied to medical therapy and other biomedical fields.
[1] Bell A G 1880 Am. J. Sci. 20 305
[2] Jian X H, Cui Y Y, Xiang Y J, Han Z L 2012 Acta Phys. Sin. 61 217801 (in Chinese) [简小华, 崔崤峣, 向永嘉, 韩志乐 2012 61 217801]
[3] Larina I V, Larin K V, Esenaliev R O 2005 J. Phys. D: Appl. Phys. 38 2633
[4] Pramanik M, Wang L V 2009 J. Biomed. Opt. 14 054024
[5] Shao P, Cox B, Zemp R J 2011 Appl. Opt. 50 3145
[6] Sigrist M W 1986 J. Appl. Phys. 60 R83
[7] Burmistrova L V, Karabutov A A, Rudenko O V, Cherepetskaya E B 1979 Sov. Phys. Acoust. 25 348
[8] Welch A J, Gemert M J C V 2011 Optical-Thermal Response of Laser-Irradiated Tissue (2nd Ed.) (New York: Springer) pp3-947
[9] Seip R, Ebbini E S 1995 IEEE Trans. Bio-Med. Eng. 42 828
[10] Steiner P, Botnar R, Dubno B, Zimmermann G G, Gazelle G S, Debatin J F 1998 Radiology 206 803
[11] Graham S J, Bronskill M J, Henkelman R M 1998 Magn. Reson. Med. 39 198
[12] Xu M H, Wang L H V 2006 Rev. Sci. Instrum. 77 041101
[13] Jiao Y, Jian X H, Xiang Y J, Cui Y Y 2013 Acta Phys. Sin. 62 087803 (in Chinese) [焦阳, 简小华, 向永嘉, 崔崤峣 2013 62 087803]
[14] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5845 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5845]
[15] Li Z, Chen H, Zhou F, Li H, Chen W R 2015 Sensors-Basel 15 5583
[16] Daoudi K, van Es P, Manohar S, Steenbergen W 2013 J. Biomed. Opt. 18 116009
[17] Huang C, Nie L, Schoonover R W, Wang L V, Anastasio M A 2012 J. Biomed. Opt. 17 061211
[18] Gusev V E 1993 Laser Optoacoustics (New York: American Institute of Physics) pp1-271
[19] Yin J, Tao C, Liu X J 2015 Acta Phys. Sin. 64 098102 (in Chinese) [殷杰, 陶超, 刘晓峻 2015 64 098102]
[20] Sethuraman S, Amirian J H, Litovsky S H, Smalling R W, Emelianov S Y 2008 Opt. Express 16 3362
[21] Tromberg B J, Shah N, Lanning R, Cerussi A, Espinoza J, Pham T, Svaasand L, Butler J 2000 Neoplasia 2 26
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[1] Bell A G 1880 Am. J. Sci. 20 305
[2] Jian X H, Cui Y Y, Xiang Y J, Han Z L 2012 Acta Phys. Sin. 61 217801 (in Chinese) [简小华, 崔崤峣, 向永嘉, 韩志乐 2012 61 217801]
[3] Larina I V, Larin K V, Esenaliev R O 2005 J. Phys. D: Appl. Phys. 38 2633
[4] Pramanik M, Wang L V 2009 J. Biomed. Opt. 14 054024
[5] Shao P, Cox B, Zemp R J 2011 Appl. Opt. 50 3145
[6] Sigrist M W 1986 J. Appl. Phys. 60 R83
[7] Burmistrova L V, Karabutov A A, Rudenko O V, Cherepetskaya E B 1979 Sov. Phys. Acoust. 25 348
[8] Welch A J, Gemert M J C V 2011 Optical-Thermal Response of Laser-Irradiated Tissue (2nd Ed.) (New York: Springer) pp3-947
[9] Seip R, Ebbini E S 1995 IEEE Trans. Bio-Med. Eng. 42 828
[10] Steiner P, Botnar R, Dubno B, Zimmermann G G, Gazelle G S, Debatin J F 1998 Radiology 206 803
[11] Graham S J, Bronskill M J, Henkelman R M 1998 Magn. Reson. Med. 39 198
[12] Xu M H, Wang L H V 2006 Rev. Sci. Instrum. 77 041101
[13] Jiao Y, Jian X H, Xiang Y J, Cui Y Y 2013 Acta Phys. Sin. 62 087803 (in Chinese) [焦阳, 简小华, 向永嘉, 崔崤峣 2013 62 087803]
[14] Wu D, Tao C, Liu X J 2010 Acta Phys. Sin. 59 5845 (in Chinese) [吴丹, 陶超, 刘晓峻 2010 59 5845]
[15] Li Z, Chen H, Zhou F, Li H, Chen W R 2015 Sensors-Basel 15 5583
[16] Daoudi K, van Es P, Manohar S, Steenbergen W 2013 J. Biomed. Opt. 18 116009
[17] Huang C, Nie L, Schoonover R W, Wang L V, Anastasio M A 2012 J. Biomed. Opt. 17 061211
[18] Gusev V E 1993 Laser Optoacoustics (New York: American Institute of Physics) pp1-271
[19] Yin J, Tao C, Liu X J 2015 Acta Phys. Sin. 64 098102 (in Chinese) [殷杰, 陶超, 刘晓峻 2015 64 098102]
[20] Sethuraman S, Amirian J H, Litovsky S H, Smalling R W, Emelianov S Y 2008 Opt. Express 16 3362
[21] Tromberg B J, Shah N, Lanning R, Cerussi A, Espinoza J, Pham T, Svaasand L, Butler J 2000 Neoplasia 2 26
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