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采用非线性动力学方法研究脑精神疾病是近年来国内外学者研究的热点和趋势. 针对脑精神疾病的研究和诊断中缺少客观有效的量化参数和量化指标的状况，提出了一种根据对时间序列功率谱划分而定义的谱熵，然后用其计算和分析脑电信号谱熵的方法. 通过数据仿真试验证明该谱熵和信号活跃性之间存在正相关关系. 基于这种相关性，应用该方法对抑郁症患者和正常对照组的脑电信号功率谱熵进行了数值计算，然后进行了分析对比和统计检验. 实验结果表明：抑郁症患者脑电信号的功率谱熵在部分脑区显著弱于正常健康人. 证明该谱熵能够表征大脑电生理活动状况，提供反映其活动性强弱的信息，可以作为度量大脑电生理活动性的一个参数. 这对于能否将该功率谱熵作为诊断脑精神疾病的物理参数具有积极意义.A method is proposed to calculate and analyze electro-encephalogram signal to improve the situation that there is an urgent need for an effective quantitative indicator to describe brain mental disorders. The method defines a spectral entropy in terms of the power spectrum division of time series. Then, the entropy is applied to numerical calculation of electroencephalogram signals of depression patients and normal control group. Meanwhile, the differences are compared between them. Experimental results show that the power spectral entropy in depression patients is significantly weaker than the normal healthy people's in some brain regions. Further analysis proves two facts. One is that the entropy is positively correlated to brain electrical physiological activity, and the other tells that the entropy can be used as a parameter to measure brain electrical activity, to characterize brain electrical physiological activities, and to provide the activity intensity information. This paper determines that the power spectral entropy for electroencephalogram plays an important role in diagnosis of brain mental disorder.
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Keywords:
- power spectral entropy /
- electroencephalogram signal /
- activity /
- depression
[1] Sadock B J, Sadock V A, Ruiz P 2008 Kaplan Sadock's Comprehensive Textbook of Psychiatry, (9th Ed.), (United States: Lippincott Williams and Wilkings) p1647
[2] [3] Xie Y, Xu J X, Yang H J, Hu S J 2002 Acta Phys. Sin. 51 205 (in Chinese)[谢勇, 徐健学, 杨红军, 胡三觉 2002 51 205]
[4] [5] Meng Q F, Zhou W D, Chen Y H, Peng Y H 2010 Acta Phys. Sin. 59 123 (in Chinese)[孟庆芳, 周卫东, 陈月辉, 彭玉华 2010 59 123]
[6] You R Y, Chen Z, Xu S C, Wu B X 2004 Acta Phys. Sin. 53 2882 (in Chinese)[游荣义, 陈忠, 徐慎初, 吴伯僖 2004 53 2882]
[7] [8] Bian H R, Wang J, Han C X, Deng B, Wei X L, Che Y Q 2011 Acta Phys. Sin. 60 118701 (in Chinese)[边洪瑞, 王江, 韩春晓, 邓斌, 魏熙乐, 车艳秋 2011 60 118701]
[9] [10] [11] Ma Q L, Bian C H, Wang J 2010 Acta Phys. Sin. 59 4480 (in Chinese)[马千里, 卞春花, 王俊 2010 59 4480]
[12] Lim J H, Khang E J, Lee T H, Kim I H, Maeng S E, Lee J W 2013 Phys. Lett. A 377 2542
[13] [14] Wang J, Zhao D Q 2012 Chin. Phys. B 21 028703
[15] [16] Fang X L, Jiang Z L 2007 Acta Phys. Sin. 56 7330 (in Chinese)[方小玲, 姜宗来 2007 56 7330]
[17] [18] [19] Liu X F, Yu W L 2008 Acta Phys. Sin. 57 2587 (in Chinese)[刘小峰, 俞文莉 2008 57 2587]
[20] [21] Zhang M, Wang J 2013 Acta Phys. Sin. 62 038701 (in Chinese)[张梅, 王俊 2013 62 038701]
[22] Wu S, Lin J, Zhang M L, Wang J 2013 Acta Phys. Sin. 62 238701 (in Chinese)[吴莎, 李锦, 张明丽, 王俊 2013 62 238701]
[23] [24] Ignaccolo M, Latka M, Jernajczyk W, Grigolini P, West B J 2010 J. Biol. Phys. 36 185
[25] [26] Ignaccolo M, Latka M, Jernajczyk W, Grigolini P, West B J 2010 Phys. Rev. E 81 031909
[27] [28] Zhang W Q, Qiu L, Xiao Q, Yang H J, Zhang Q J, Wang J Y 2012 Phys. Rev. E 86 056107
[29] [30] [31] Yao W P, Liu T B, Dai J F, Wang J 2014 Acta Phys. Sin. 63 078704 (in Chinese)[姚文坡, 刘铁兵, 戴加飞, 王俊 2014 63 078704]
[32] Phillip P A, Chiu F L, Nick S J 2009 Phys. Rev. E 79 011915
[33] [34] [35] Malihe S, Serajeddin K, Reza B 2009 Artif. Intell. Med. 47 263
[36] Porporato A, Rigby J R, Daly E 2007 Phys. Rev. Lett. 98 094101
[37] [38] Huang J H, Liu N H, Liu J T, Yu T B, He X 2010 Chin. Phys. B 19 110307
[39] [40] Lu H X, Zhao B 2006 Chin. Phys. 15 1914
[41] -
[1] Sadock B J, Sadock V A, Ruiz P 2008 Kaplan Sadock's Comprehensive Textbook of Psychiatry, (9th Ed.), (United States: Lippincott Williams and Wilkings) p1647
[2] [3] Xie Y, Xu J X, Yang H J, Hu S J 2002 Acta Phys. Sin. 51 205 (in Chinese)[谢勇, 徐健学, 杨红军, 胡三觉 2002 51 205]
[4] [5] Meng Q F, Zhou W D, Chen Y H, Peng Y H 2010 Acta Phys. Sin. 59 123 (in Chinese)[孟庆芳, 周卫东, 陈月辉, 彭玉华 2010 59 123]
[6] You R Y, Chen Z, Xu S C, Wu B X 2004 Acta Phys. Sin. 53 2882 (in Chinese)[游荣义, 陈忠, 徐慎初, 吴伯僖 2004 53 2882]
[7] [8] Bian H R, Wang J, Han C X, Deng B, Wei X L, Che Y Q 2011 Acta Phys. Sin. 60 118701 (in Chinese)[边洪瑞, 王江, 韩春晓, 邓斌, 魏熙乐, 车艳秋 2011 60 118701]
[9] [10] [11] Ma Q L, Bian C H, Wang J 2010 Acta Phys. Sin. 59 4480 (in Chinese)[马千里, 卞春花, 王俊 2010 59 4480]
[12] Lim J H, Khang E J, Lee T H, Kim I H, Maeng S E, Lee J W 2013 Phys. Lett. A 377 2542
[13] [14] Wang J, Zhao D Q 2012 Chin. Phys. B 21 028703
[15] [16] Fang X L, Jiang Z L 2007 Acta Phys. Sin. 56 7330 (in Chinese)[方小玲, 姜宗来 2007 56 7330]
[17] [18] [19] Liu X F, Yu W L 2008 Acta Phys. Sin. 57 2587 (in Chinese)[刘小峰, 俞文莉 2008 57 2587]
[20] [21] Zhang M, Wang J 2013 Acta Phys. Sin. 62 038701 (in Chinese)[张梅, 王俊 2013 62 038701]
[22] Wu S, Lin J, Zhang M L, Wang J 2013 Acta Phys. Sin. 62 238701 (in Chinese)[吴莎, 李锦, 张明丽, 王俊 2013 62 238701]
[23] [24] Ignaccolo M, Latka M, Jernajczyk W, Grigolini P, West B J 2010 J. Biol. Phys. 36 185
[25] [26] Ignaccolo M, Latka M, Jernajczyk W, Grigolini P, West B J 2010 Phys. Rev. E 81 031909
[27] [28] Zhang W Q, Qiu L, Xiao Q, Yang H J, Zhang Q J, Wang J Y 2012 Phys. Rev. E 86 056107
[29] [30] [31] Yao W P, Liu T B, Dai J F, Wang J 2014 Acta Phys. Sin. 63 078704 (in Chinese)[姚文坡, 刘铁兵, 戴加飞, 王俊 2014 63 078704]
[32] Phillip P A, Chiu F L, Nick S J 2009 Phys. Rev. E 79 011915
[33] [34] [35] Malihe S, Serajeddin K, Reza B 2009 Artif. Intell. Med. 47 263
[36] Porporato A, Rigby J R, Daly E 2007 Phys. Rev. Lett. 98 094101
[37] [38] Huang J H, Liu N H, Liu J T, Yu T B, He X 2010 Chin. Phys. B 19 110307
[39] [40] Lu H X, Zhao B 2006 Chin. Phys. 15 1914
[41]
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