The left-handed material, whose permittivity and permeability are simultaneously negative, has some exotic electromagnetic properties, and is one of the most absorbing subjects in recent physical academic domain. This paper suggests that a tunable left-handed metamaterial can be realized by using ferrite as the substrate of metallic wire structure, owing to the field dependence of ferrite's permeability. Finite element method was used to simulate the effect of substrate properties on the effective properties of a metamaterial slab. With the rise of substrate permittivity or permeability, the resonance frequency drops significantly. Ferroxplana has been prepared, and the field dependence of its permeability was studied.