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姜黄素是一种具有抗炎、抗氧化及抗癌等作用的常用药物, 但是其在水中的溶解度较低. 近年来, 药物共晶是一种增强水溶性有限药物溶解度和溶解性的有效方法. 基于此, 本文利用太赫兹时域光谱技术(THz-TDS)研究了姜黄素与邻苯二酚共晶的太赫兹光谱. 首先测试了姜黄素、邻苯二酚、二者物理混合及其共晶在0.5—3.5 THz的实验谱. 实验数据显示共晶获得的位于3.31 THz处的吸收峰明显区别于原料物质, 表明THz-TDS可以有效鉴别姜黄素、邻苯二酚及其共晶体; 基于密度泛函理论, 对姜黄素与邻苯二酚共晶体可能存在的4种理论晶型进行结构优化与频谱模拟, 其中理论晶型Ⅲ模拟结果与实验数据比较符合. 研究发现, 共晶体是通过姜黄素的羰基C10=O3与邻苯二酚的羟基O61—H55形成氢键而成, 共晶的THz特征吸收峰是在氢键带动下由共晶中两分子的官能团共同作用产生的.Curcumin (CUR) is a commonly used pharmaceutical with anti-inflammatory, antioxidant and anti-cancer effects, but its solubility in water is relatively low. In recent years, pharmaceutical co-crystal has been an effective method of enhancing the solubility of limited water-soluble pharmaceuticals. Based on this, terahertz time-domain spectroscopy (THz-TDS) is used to study the THz spectra of curcumin-catechol co-crystal. Firstly, the experimental spectra of curcumin, catechol (CTL), their physical mixture and their co-crystal are measured in a range of 0.5–3.5 THz, respectively. The experimental data show that CUR obtains six THz absorption peaks, while CTL possess three THz absorption peaks, the physical mixture obtains four absorption peaks, and their CUR-CTL co-crystal obtains three absorption peaks. These results indicate that THz-TDS can effectively identify curcumin, catechol and their co-crystals. The fact that the absorption peak at 3.31 THz obtained in co-crystal is entirely different from those of raw materials, implying that new weak interactional forces are generated between CUR molecule and CTL molecule, the co-crystal forms a new three-dimensional structure compared with their raw materials. These results are also verified by X-ray diffraction spectra of raw material and their Co-crystal. Moreover, four possible theoretical forms of curcumin-catechol co-crystal are optimized and simulated by using density functional theory (DFT). The calculated results indicate that the data of co-crystal form III are in good agreement with the experimental spectrum, and the simulation effectively reconstructs the experimental spectrum. So it can be inferred that the co-crystal is formed through the hydrogen bond between the carbonyl C10=O3 of CUR and the hydroxy O61-H55 of CTL. In addition, depending on the good match between experimental data and theoretical results, it is found that the three absorption peaks in the co-crystal do not origin from the action of a single molecule, but the joint action of the functional groups of the two molecules under the driving by the hydrogen bond. The existence of weak interaction forces, such as the hydrogen bond, not only changes the structural parameters of the two molecules, but also reestablishes a new intermolecular force, which then affects the interactional motions of the co-crystal. This fact directly leads the CUR-CTL co-crystal to exhibit THz absorption peaks different from those of raw materials in the THz band.
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Keywords:
- curcumin /
- co-crystal /
- terahertz wave /
- absorption spectrum
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图 2 CUR, CTL, CUR-CTL物理混合、CUR-CTL共晶的THz谱
Fig. 2. THz spectra of CUR, CTL, CUR-CTL physical mixing, and CUR-CTL co-crystal.
图 3 CUR, CTL, CUR-CTL共晶的X衍射实验谱
Fig. 3. X-ray diffraction experimental spectra of CUR, CTL, and CUR-CTL co-crystal.
图 4 CUR-CTL共晶分子结构 (a)晶型Ⅰ; (b)晶型Ⅱ; (c)晶型Ⅲ; (d)晶型Ⅳ
Fig. 4. Molecular structures of CUR-CTL co-crystal: (a) Form I; (b) form II; (c) form III; (d) form Ⅳ.
图 5 CUR-CTL共晶的实验与模拟THz图谱
Fig. 5. Experimental and simulated THz spectra of CUR-CTL co-crystal.
图 6 CUR-CTL共晶在不同峰位的振动模式 (a) 1.03 THz; (b) 1.95 THz; (c) 3.34 THz
Fig. 6. Vibrational modes of CUR-CTL co-crystal at different peaks: (a) 1.03 THz; (b) 1.95 THz; (c) 3.34 THz.
表 2 CUR-CTL共晶体实验和理论计算数据
Table 2. The results of experimental and calculated data of CUR-CTL co-crystal.
Frequency/THz Vibrational mode Expt. Theo. 1.03 1.03 Bending of C34—C10—C32, Out-of-plane oscillation of R2 and R2, In plane oscillation of CTL 1.95 1.95 Out of plane torsion of -C16H3 and R2, Out of plane rocking oscillation of CTL 3.31 3.34 The stretching vibration of hydrogen bond C10=O30···H55—O61, Swing of C30—C32—C10, Out-of-plane oscillation of R2 and R1 
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[1] Kulkarni A, Shete S, Hol V, Bachhav R 2020 AJPS 13 104
Google Scholar
[2] Prabhakar P, Giridhar S 2019 Indian J. Pharm. Educ. 53 563
Google Scholar
[3] Novena L. M, Athimoolam S, Anitha R, Bahadur S A 2021 J. Mol. Struct. 1249 2022
Google Scholar
[4] Akshita J, Mansi P, Neelima D, Kunal C, Maninder 2022 J. Pharm. 111 2788
Google Scholar
[5] George C P, Thorat S H, Shaligram P S, Suresha P R, Gonnade R G 2020 Crystengcomm 22 6137
Google Scholar
[6] Sakamoto N, Tsuno N, Koyama R, Gato K, Titapiwatanakun V, Takatori K, Fukami T 2021 Chem. Pharm. Burl. 69 1995
Google Scholar
[7] Liu L X, Liu M, Zhang Y, Feng Y, Wu L, Zhang L, Zhang Y J, Liu Y L, Zou D Y 2022 J. Mol. Struct. 1250 1318
[8] Yong D, Hong X F, Qi Z, Hui L Z, Zhi H 2016 Spectrochim. Acta. A 153 580
Google Scholar
[9] Wan M, Fang J Y, Xue J D, Liu J J, Qin J Y, Hong Z, Li J S, D Y 2022 Int. J. Mol. Sci. 23 8550
Google Scholar
[10] 段铜川, 闫韶健, 赵妍, 孙庭钰, 李阳梅, 朱智 2021 70 248702
Google Scholar
Duan T C, Yan S j, Zhao Y, Sun T Y, Li Y G, Zhu Z 2021 Acta Phys. Sin. 70 248702
Google Scholar
[11] 郑转平, 刘榆杭, 曾方, 赵帅宇, 朱礼鹏 2023 72 083201
Google Scholar
Zheng Z P, Liu Y H, Zeng F, Zhao S Y, Zhu L P 2023 Acta Phys. Sin. 72 083201
Google Scholar
[12] Cai Q, Xue J D, Wang Q, Du Y 2017 Spectrochim. Acta. A 186 29
Google Scholar
[13] Wang P F, Zhao J T, Zhang Y M, Zhu Z J, Liu L Y, Zhao H G, Yang X C, Yang X N, Sun X H, He M G 2022 Int. J. Pharmaceut. 620 121759
Google Scholar
[14] Margaret D, Mizuki M, Kei H, Timothy K 2020 J. Phys. Chem. A 124 9793
Google Scholar
[15] Luczynska, Katarzyna, Druzbicki, Kacper, Lyczko, Krzysztof, Dobrowolski 2015 J. Phys. Chem. B 119 6852
Google Scholar
[16] Adrieli S H, Matheus G L, Radharani B 2022 Ind. Crop. Prod. 177 114501
Google Scholar
[17] Yao T M, Srinivas J W 2022 Food Hydrocolloids 126 107466
Google Scholar
[18] Saffarionpour S, Diosady L L 2022 Curr. Opin. Food. Sci. 43 155
Google Scholar
[19] Sakineh M, Ali H A, Pouya M 2020 Chromatographia 83 1293
Google Scholar
[20] 程桂林, 邓彩赟, 蒋成君 2018 中国现代应用药学 35 5
Google Scholar
Cheng G L, Deng G Y, Jiang C J 2018 Chin. J. Mod. Drug App. 35 5
Google Scholar
[21] Ribas M M, Sakata G S, Santos A E, Magro C D, Aguiar G P, Vladimir M L 2019 J. Supercrit. Fluid. 152 104564
Google Scholar
[22] Indumathi S, Jenna S M, Sohrab R, Sameer D V 2018 J. Chem. Data. 63 3652
Google Scholar
[23] 邓彩赟, 蒋成君 2018 浙江科技学院学报 30 16
Google Scholar
Deng C Y, Jiang C J 2018 J. Zhejiang Univ. Sci. B 30 16
Google Scholar
[24] Roothan C C 1951 Rev. Mod. Phys. 23 69
Google Scholar
[25] Stephens P J, Devlin F J, Chabalowski C F 1994 J. Phys. Chem. 98 11623
Google Scholar
[26] Chen T, Yu L X, Tang Z Q, Li Z, Hu F G 2022 Chem. Phys. 562 111676
Google Scholar
[27] Otsuka Y T, Ito A, Takeuchi M, Sasaki T, Tanaka H J 2020 J. Brug Deliv. Sci. Tec. 56 101215
Google Scholar
[28] Hjorth H T, Jan K, Arvid M, Bertil S, Znzell C R, Eric J B 1982 Acta Chem. Sca. 36 475
Google Scholar
[29] Wunderlich H, Mootz D 1971 Acta Cry. Sect. B 27 1684
Google Scholar
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