基于多时窗波束形成器方法的心脏磁场信号分析

王伟远; 蒋式勤; 周大方; 朱嘉辰; 闫玉蕊; 权薇薇

doi:10.7498/aps.63.248702

摘要

提出了一种多时窗的波束形成器, 可以从多通道心脏磁场测量数据中估计强、弱和持续时间长短不同的等效电流源. 这种心脏电活动可视化技术将有助于相关心脏疾病的诊断. 通过两个已知电流源的仿真实验说明了这种方法的可行性. 并通过一个完全左束支传导阻滞和一个完全右束支传导阻滞病人的心脏QRS段磁场测量数据的源估计结果及其二维电兴奋传播图的比较, 分析了用这种成像方法揭示的心脏电生理现象.

关键词:

A beamformer method based on multiple time windows is proposed to estimate the equivalent current sources of different strength and duration from multi-channel magnetocardiography data. This technique of visualizing cardiac electric activities will be a great help to the diagnosis of relevant heart diseases. Feasibility of this beamformer method has been proved by simulation experiments of two known sources. Source estimation results and two-dimensional excitation propagation diagrams of a complete left bundle branch block and a complete right bundle branch block patients during QRS complex are taken to be compared. The revealed characteristics of their electrophysiological phenomena are analyzed.

Keywords:

作者及机构信息

1.
同济大学电子与信息工程学院, 上海 201804;

2.
上海交通大学医学院瑞金医院心内科, 上海 200025

基金项目: 国家自然科学基金(批准号: 60771030)、国家高技术研究发展计划(批准号: 2008AA02Z308)、上海市重点基础研究发展计划(批准号: 08JC1421800)、上海市重点学科建设项目(批准号: B004)、信息功能材料国家重点实验室(中国科学院上海微系统与信息技术研究所) 开放课题和上海市医学图像处理与计算机辅助手术重点实验室开放课题(批准号: 13DZ2272200-2)资助的课题.

Authors and contacts

1.
School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China;

2.
Department of Cardiology, Rui Jin Hospital and College of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Funds: Project supported by the National Natural Science Foundation of China (Grant No. 60771030), the National High-Technology Research and Development Program of China (Grant No. 2008AA02Z308), the Shanghai Science and Technology Development Foundation, China (Grant No. 08JC1421800), the Shanghai Leading Academic Discipline Project, China (Grant No. B004), the Open Project of State Key Laboratory of Function Materials for Information, China (Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences), and the Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, China (Grant No. 13DZ2272200-2).

参考文献

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[2]	Nenonen J, Katila T, Leinio M, Montonen J, Makijarvi M, Siltanen P 1991 IEEE Trans. Biomed. Eng. 38 648
[3]	Ziolkowski M, Haueisen J, Leder U 2002 IEEE Trans. Biomed. Eng. 49 1379
[4]	Andrä W, Nowak H 2007 Magnetism in Medicine: A Handbook (2 Ed.) (Berlin: Wiley-VCH Verlag GmbH & Co. KGaA) pp101-163
[5]	Zhang S L, Wang Y L, Wang H W, Jiang S Q, Xie X M 2009 Phys. Med. Biol. 54 4793
[6]	de Melis M, Tanaka K, Uchikawa Y 2010 IEEE Trans. Magn. 46 1203
[7]	Tolstrup K, Madsen B E, Ruiz J A, Greenwood S D, Camacho J, Siegel R J, Gertzen H C, Park J W, Smars P A 2006 Cardiology 106 270
[8]	Lim K H, Chung N, Ko Y G, Lee Y H, Park Y K 2009 IEEE Trans. Magn. 45 2890
[9]	On K, Watanabe S, Yamada S, Takeyasu N, Nakagawa Y, Nishina H, Morimoto T, Aihara H, Kimura T, Sato Y 2007 Circulation Journal: Official Journal of the Japanese Circulation Society 71 1586
[10]	Leeuwen P V, Hailer B, Beck A, Eiling G, Grönemeyer D 2011 Ann. Noninvas. Electro. 16 379
[11]	Robinson S E, Vrba J 1999 The 11th International Conference on Biomagnetism (Sendai: Tohoku University Press) p302
[12]	Sekihara K, Nagarajan S S, Poeppel D, Marantz A, Miyashita Y 2000 IEEE Trans. Biomed. Eng. 48 760
[13]	Kim K, Lee Y, Kwon H, Kim J, Bae J 2006 Comput. Bio. Med. 36 253
[14]	Xia L 1995 Ph. D. Dissertation (Hangzhou: Zhejiang University) (in Chinese) [夏灵 1995 博士学位论文 (杭州: 浙江大学)]
[15]	Tang F K, Hua N, Lu H, Tang X Z, Wang Q, Ma P 2011 Chin. Phys. B 20 010702
[16]	Zhang C, Shou G F, Lu H, Hua N, Tang X Z, Xia L, Ma P, Tang F K 2013 Chin. Phys. B 22 90701
[17]	van Veen B D, van Drongelen W, Yuchtman M, Suzuki A 1997 IEEE Trans. Biomed. Eng. 44 867
[18]	Kim K, Kim D, Shim E B, Lee Y H, Kwon H, Park Y K 2007 The Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart & the International Conference on Functional Biomedical Imaging Hangzhou, China October 12-14, 2007 p316
[19]	Im U B, Kwon S S, Kim K, Lee Y H, Park Y K, Youn C H, Shim E B 2008 Prog. Biophys. Mol. Bio. 96 339
[20]	Wang W Y, Zhou D F, Jiang S Q 2012 International Conference on System Simulation Shanghai, China, April 6-9, 2012 p293
[21]	Wang W Y, Zhao C, Lin Y Z, Zhang S L, Xie X M, Jiang S Q 2013 Acta Phys. Sin. 62 148703 (in Chinese) [王伟远, 赵晨, 林玉章, 张树林, 谢晓明, 蒋式勤 2013 62 148703]
[22]	Ravan M 2014 IEEE Trans. Biomed. Eng. 61 535
[23]	Zhu J J, Jiang S Q, Wang W Y, Zhao C, Wu Y H, Luo M, Quan W W 2013 Chin. Phys. B 22 048702

施引文献

[1]	Cohen D, Edelsack E A, Zimmerman J E 1970 Appl. Phys. Lett. 16 278
[2]	Nenonen J, Katila T, Leinio M, Montonen J, Makijarvi M, Siltanen P 1991 IEEE Trans. Biomed. Eng. 38 648
[3]	Ziolkowski M, Haueisen J, Leder U 2002 IEEE Trans. Biomed. Eng. 49 1379
[4]	Andrä W, Nowak H 2007 Magnetism in Medicine: A Handbook (2 Ed.) (Berlin: Wiley-VCH Verlag GmbH & Co. KGaA) pp101-163
[5]	Zhang S L, Wang Y L, Wang H W, Jiang S Q, Xie X M 2009 Phys. Med. Biol. 54 4793
[6]	de Melis M, Tanaka K, Uchikawa Y 2010 IEEE Trans. Magn. 46 1203
[7]	Tolstrup K, Madsen B E, Ruiz J A, Greenwood S D, Camacho J, Siegel R J, Gertzen H C, Park J W, Smars P A 2006 Cardiology 106 270
[8]	Lim K H, Chung N, Ko Y G, Lee Y H, Park Y K 2009 IEEE Trans. Magn. 45 2890
[9]	On K, Watanabe S, Yamada S, Takeyasu N, Nakagawa Y, Nishina H, Morimoto T, Aihara H, Kimura T, Sato Y 2007 Circulation Journal: Official Journal of the Japanese Circulation Society 71 1586
[10]	Leeuwen P V, Hailer B, Beck A, Eiling G, Grönemeyer D 2011 Ann. Noninvas. Electro. 16 379
[11]	Robinson S E, Vrba J 1999 The 11th International Conference on Biomagnetism (Sendai: Tohoku University Press) p302
[12]	Sekihara K, Nagarajan S S, Poeppel D, Marantz A, Miyashita Y 2000 IEEE Trans. Biomed. Eng. 48 760
[13]	Kim K, Lee Y, Kwon H, Kim J, Bae J 2006 Comput. Bio. Med. 36 253
[14]	Xia L 1995 Ph. D. Dissertation (Hangzhou: Zhejiang University) (in Chinese) [夏灵 1995 博士学位论文 (杭州: 浙江大学)]
[15]	Tang F K, Hua N, Lu H, Tang X Z, Wang Q, Ma P 2011 Chin. Phys. B 20 010702
[16]	Zhang C, Shou G F, Lu H, Hua N, Tang X Z, Xia L, Ma P, Tang F K 2013 Chin. Phys. B 22 90701
[17]	van Veen B D, van Drongelen W, Yuchtman M, Suzuki A 1997 IEEE Trans. Biomed. Eng. 44 867
[18]	Kim K, Kim D, Shim E B, Lee Y H, Kwon H, Park Y K 2007 The Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart & the International Conference on Functional Biomedical Imaging Hangzhou, China October 12-14, 2007 p316
[19]	Im U B, Kwon S S, Kim K, Lee Y H, Park Y K, Youn C H, Shim E B 2008 Prog. Biophys. Mol. Bio. 96 339
[20]	Wang W Y, Zhou D F, Jiang S Q 2012 International Conference on System Simulation Shanghai, China, April 6-9, 2012 p293
[21]	Wang W Y, Zhao C, Lin Y Z, Zhang S L, Xie X M, Jiang S Q 2013 Acta Phys. Sin. 62 148703 (in Chinese) [王伟远, 赵晨, 林玉章, 张树林, 谢晓明, 蒋式勤 2013 62 148703]
[22]	Ravan M 2014 IEEE Trans. Biomed. Eng. 61 535
[23]	Zhu J J, Jiang S Q, Wang W Y, Zhao C, Wu Y H, Luo M, Quan W W 2013 Chin. Phys. B 22 048702

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