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Based on the three-dimensional structure of NaK channel, the permeabilities of the NaK channel for Na+, K+, Rb+, Ca2+ ions and the Ba2+ ion blockage mechanisms are investigated. The results show that the interaction is fundamental for determining the selectivities of the channels and the potential curve reflects the external behaviors for the permeabilities of different ions.
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Keywords:
- The NaK channel /
- density functional theory /
- Brownian dynamic /
- permeability
[1] Tang Y Q 1998 Chemistry of Life (Hunan Science & Technology Press) P96 ( in Chinese)[唐有祺 1998 生命的化学(湖南科学技术出版社)第96 页]
[2] Wang H Q,Yu LC,Chen Y 2009 Acta Phys. Sin. 58 5070 ( in Chinese) [王慧巧、俞连春、陈 勇 2009 58 〖3] Qiao X Y, Li G, Dong Y E, He B J 2008 Acta Phys. Sin. 57 1259( in Chinese) [乔晓艳、李 刚、董有尔、贺秉军 2008 57 〖4] Heginbotham L, Lu Z, Abramson T, MacKinnon R 1994 Biophys. J. 66 1061
[3] So I, Ashmole I, Davies N W, Sutcliffe M J, Stanfield P R 2001 J. Physiol. 53 37
[4] Shi N, Ye S, Alam A, Chen L P, Jiang Y X 2006 Nature 440 570
[5] Zagotta W N 2006 Nature 440 427
[6] Alam A, Shi N, Jiang Y X 2007 Proc. Natl. Acad. Sci. U. S. A. 104 15334
[7] Kaupp U B, Seifert R 2002 Physiol. Rev. 82 769
[8] Jiang Y, Pico A, Cadene M, Chait B T, MacKinnon R 2001 Neuron 29 593
[9] Mashl R J, Tang Y, Schnitzer J, Jakobsson E 2001 Biophys J. 81 2473
[10] Zhang R Q,Bu Y X,Li Sh T 2000 Chinese Science B 30 419 (in Chinese)[张瑞勤、步宇翔、李述汤 2000 中国科学 B 30 419]
[11] Chen L, Xu C, Zhang X F 2009 Acta Phys. Sin. 58 1603( in Chinese) [陈 亮、徐 灿、张小芳 2009 58 1603]
[12] Fang F, Jiang G, Wang H Y 2006 Acta Phys. Sin. 55 2241( in Chinese)[方 芳、蒋 刚、王红艳 2006 55 2241]
[13] Rebecca L 1992 Phy. Rev. A 15 600
[14] Zhan Y, Zhao T J, Yu H, Song Y L 2002 Chin. Phys. 11 624
[15] Hille B 2001 Ion Channels of Excitable Membranes (Sinauer Associates, INC. Publishers 3rd edition) p72
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[1] Tang Y Q 1998 Chemistry of Life (Hunan Science & Technology Press) P96 ( in Chinese)[唐有祺 1998 生命的化学(湖南科学技术出版社)第96 页]
[2] Wang H Q,Yu LC,Chen Y 2009 Acta Phys. Sin. 58 5070 ( in Chinese) [王慧巧、俞连春、陈 勇 2009 58 〖3] Qiao X Y, Li G, Dong Y E, He B J 2008 Acta Phys. Sin. 57 1259( in Chinese) [乔晓艳、李 刚、董有尔、贺秉军 2008 57 〖4] Heginbotham L, Lu Z, Abramson T, MacKinnon R 1994 Biophys. J. 66 1061
[3] So I, Ashmole I, Davies N W, Sutcliffe M J, Stanfield P R 2001 J. Physiol. 53 37
[4] Shi N, Ye S, Alam A, Chen L P, Jiang Y X 2006 Nature 440 570
[5] Zagotta W N 2006 Nature 440 427
[6] Alam A, Shi N, Jiang Y X 2007 Proc. Natl. Acad. Sci. U. S. A. 104 15334
[7] Kaupp U B, Seifert R 2002 Physiol. Rev. 82 769
[8] Jiang Y, Pico A, Cadene M, Chait B T, MacKinnon R 2001 Neuron 29 593
[9] Mashl R J, Tang Y, Schnitzer J, Jakobsson E 2001 Biophys J. 81 2473
[10] Zhang R Q,Bu Y X,Li Sh T 2000 Chinese Science B 30 419 (in Chinese)[张瑞勤、步宇翔、李述汤 2000 中国科学 B 30 419]
[11] Chen L, Xu C, Zhang X F 2009 Acta Phys. Sin. 58 1603( in Chinese) [陈 亮、徐 灿、张小芳 2009 58 1603]
[12] Fang F, Jiang G, Wang H Y 2006 Acta Phys. Sin. 55 2241( in Chinese)[方 芳、蒋 刚、王红艳 2006 55 2241]
[13] Rebecca L 1992 Phy. Rev. A 15 600
[14] Zhan Y, Zhao T J, Yu H, Song Y L 2002 Chin. Phys. 11 624
[15] Hille B 2001 Ion Channels of Excitable Membranes (Sinauer Associates, INC. Publishers 3rd edition) p72
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