In this paper, a porous silicon-calcium fluoride hybrid plasmonic waveguide (PS-CaF
2 HPW) with an asymmetric silver film is studied. The PS-CaF
2 HPW is composed of a PS strip waveguide deposited with asymmetric CaF
2 and Ag thin film layers on an SiO
2 substrate. In the mid-infrared (MIR) region, the mode characteristics and waveguide sensitivity of the mode in the PS-CaF
2 HPW are simulated by using the finite element method (FEM). The results show that there are two fundamental modes (PM 1 and PM 2) with different polarization states in the PS-CaF
2 HPW. The real part of the effective refractive index (Re(
neff)), transmission loss (
α), normalized effective mode field area (
A), quality factor (
FOM) and sensitivity (
Swg) for each of the PM 1 and the PM 2 are studied and optimized. Moreover, the effect of temperature on the performances of the PS-CaF
2 HPW is also analyzed. Firstly, the mode field distributions calculated by the FEM indicate that the mode field energy for each of the PM 1 and PM 2 in the PS-CaF
2 HPW is mostly restricted to the PS layer and CaF
2 layer. Comparing with conventional dielectric waveguides, the mode field energy of the PS-CaF
2 HPW is well confined in the PS layer and CaF
2 layer. The geometric parameters of the PS-CaF
2 HPW are optimized by changing the geometric parameters (
W1,
W2, and
W3). When
W1 = 1500 nm,
W2 = 300 nm,
W3 = 70 nm, and the operating wavelength is ~3.5 μm,
α and
FOM are 0.019 dB/μm and 1594.99 for the PM 1, and
α and FOM are 0.016 dB/μm and 1335.54 for the PM 2, respectively. Secondly, the waveguide sensitivity of the PS-CaF
2 HPW is analyzed. The results show that the size of PS layer has a great influence on the waveguide sensitivity. The waveguide sensitivity decreases with the size of the PS layer increasing. In addition, the PS-CaF
2 HPW has good temperature resistance. Moreover, temperature has almost no effect on Re(
neff), nor
α nor
A nor FOM nor
Swg in a temperature range from -40 K to 40 K. Finally, the fabrication tolerances of the PS-CaF
2 HPW are demonstrated, and the good properties are maintained in a size tolerance range from -10 nm to 10 nm. With the advantages in propagation property and loss reduction, the PS-CaF
2 HPW provides a feasible label-free biochemical sensing scheme and a method of polarization control devices.