The experimental results confirmin that spiral wave can be observed in the cortex of brain and the electric signals in neurons can proprgate with spiral wave. The mechanism for the formation of spiral wave is investiaged in the regular network of Hodgkin-Huxley, which can measure the effect of ion channels, and the sprial waves with different periods are developed to occupy the network by blocking the travelling wave with defects. The basic condition for inducing spiral wave and the effect of the couling intensity are analyzed. The potential mechanism for developing spiral wave is discussed.