In this paper, we employ molecular static approach with quantum corrected Sutten-Chen many-body potential to study the elastic responses of nickel monocrystal subjected to uniaxial tensile and compressive loading, and consider three different loadings, i.e., the ［001］, ［011］ and ［111］ loding. The simulated results show that strong nonlinear effects are found in the elastic behavior of monocrystal under the ［011］ loading, while the lateral deformations are essentially isotropic under ［100］ and ［111］ loadings. The further discussions are focused on the dependence of the Young's moduli and Poisson's ratios on the applied strain, and a brief comparison with first-principles calculations is also presnted.