Multicharged xenon ions with charge up to 20 have been observed in laser ionization of xenon beam by a 25ns Nd:YAG 1064nm laser with a laser intensity of 1011—1012 W·cm-2 Experimental results indicate that the multicharged ions appeared only when the laser interacted with the middle part of the pulsed beam, and its intensity increases with the increase of the backing pressure of Xe source gas. These indicate that the clusters in the beam is essential to the production of multicharged ions. We also discuss the possible mechanism of the generation of the multicharged ions.