基于核磁共振弹性成像技术的肝纤维化分级体模研究

汪红志; 许凌峰; 俞捷; 黄清明; 王晓琰; 陆伦; 王鹤; 黄勇; 程红岩; 张学龙; 李鲠颖

doi:10.7498/aps.59.7463

摘要

肝纤维化程度以及纤维化速率的精确判断对于相应治疗手术的选择以及治疗预后评估都是至关重要的.临床上需要发展一种非侵入性的肝纤维化定量检查手段.核磁共振弹性成像技术成为实现肝纤维化分级研究的最具发展前景的技术之一.我们研制开发了可用于进行肝纤维化分级研究的实验平台,并讨论了激励装置和位移相位成像序列的技术细节,最后给出了体模的初步实验结果并对结果进行了分析.为后续体模深入研究和临床应用实验奠定基础.

关键词:

Accurate detection of liver fibrosis stage and fibrosis procession is crucial for assessing prognosis and candidacy for treatment of patients with chronic hepatic disease. A significant need exists for developing a noninvasive technique for quantitative detection of liver fibrosis stage. Magnetic resonance elasto-graphy (MRE) is one of the most repidly advancing technologies for classifying the liver fibrosis. This study establishes a platform for liver fibrosis classification, and discusses some details in developing stimulator and displacement-phase imaging pulse. At last, the preliminary result and analysis of phantom experiment are given, which would form a basis for subsequent research on phantom MRE and its clinic application.

Keywords:

作者及机构信息

(1)第二军医大学附属东方肝胆医院,上海 200438; (2)华东师范大学物理系,上海市磁共振重点实验室,上海 200062; (3)华东师范大学物理系,上海市磁共振重点实验室,上海 200062,上海理工大学医学影像工程研究所,上海 200093,上海医疗器械高等专科学校,上海 200093; (4)上海理工大学医学影像工程研究所,上海 200093; (5)上海理工大学医学影像工程研究所,上海 200093,上海医疗器械高等专科学校,上海 200093; (6)通用电器医疗系统(中国)有限公司,上海 201203

基金项目: 上海市科研创新基金(批准号:10YZ237)和上海市教育高地建设项目科研基金(批准号:P0502)资助的课题.

Authors and contacts

(1)Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China; (2)GE Healthcare (China), Shanghai 201203, China; (3)Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China; (4)Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China, Shanghai Medical Instrumentation College, Shanghai 200093, China; (5)Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China; (6)Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China, Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China, Shanghai Medical In

参考文献

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[18]	McKnight A, Kugel J, Rossman P, Manduca A, Hartmann L, Ehman R 2002 AJR 178 1411
[19]	Sinkus R, Tanter M, Xydeas T, Catheline S, Bercoff J, Fink M 2005 Magn. Reso. Imag. 23 159
[20]	Plewes B, Bishop J, Samani A, Sciarretta J 2000 Phys. Med. Biol. 45 1591
[21]	Bao S L, Gao S, Zhang S G, Zhou K, Zu Z L 2008 Chin. Phys. B 17 328
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施引文献

[1]	Huwart L, Peeters F, Sinkus R 2006 NMR Biomed. 19 173
[2]	Tian Y, Fan Z P, Gu H Y 2007 World J. Gastroenterol. 24 2626 (in Chinese) [田艳、范竹萍、顾海燕 2007 世界华人消化杂志 24 2626]
[3]	Meng Y, Talwalkar J, Glaser J, Manduca A, Grimm C, Rossman J, Fidler L, Ehman L 2007 Clin. Gastroenterol. Hepatol. 10 1207
[4]	Huwart L, Peeters F, Sinkus R, Annet L, Salameh N, Beek L, Horsmans Y, Beers B 2006 NMR Biomed. 19 173
[5]	Hamer O, Aguirre D, Casola G 2006 Radiography 26 1637
[6]	Piccinino F, Sagnelli G, Pasquale G, Giusti G 1986 J. Hepatol. 2 165
[7]	Bravo A, Sheth S, Chopra S 2001 New Eng. J. Med. 344 495
[8]	Kelleher B, Afdhal N 2005 Clin. Liver. Dis. 9 667
[9]	Rouviere O, Meng Y, Dresner A, Rossman J, Burgart L, Fidler J, Ehman R 2006 Radiology 240 440
[10]	Peeters F 2005 Proceedings of the International Society for Magnetic Resonance in Medicine Miami , USA, May 7—13, 2005 p339
[11]	Rouviere O, Meng Y, Dresner A, Rossman J, Burgart L, Fidler J, Ehman R 2005 Proceedings of the International Society for Magnetic Resonance in Medicine Miami, USA, May 7—13, 2005 p340
[12]	Klatt D, Asbach P, Rump J, Papazoglou S, Somasundaram R, Modrow J, Braun J, Sack I 2006 Invest. Radiol. 41 841
[13]	Muthupillai R, Lomas D, Rossman P, Greenleaf J, Manduca A, Ehman R 1995 Science 269 1854
[14]	Shadi F, Zhou X H, Xu H H, Royston J, Magin L 2007 Magn. Reson. Im. 25 94
[15]	Cheng J, Ni C, Zhuang T G 2006 Chin. Sci. Bull. 51 781 (in Chinese) [陈俊、倪成、庄天戈 2006 科学通报 51 781]
[16]	Wang H Z, Wen Z Q, Huang Y, Zhang X L, Cheng H Y, Li G Y 2008 Chin. J. Med. Image Tech. 11 1833 (in Chinese) [汪红志、温增庆、黄勇、张学龙、程红岩、李鲠颖 2008 中国医学影像技术 11 1833] 〖17] Xu L, Gao P Y, Lin Y 2006 Chin. J. Med. Phys. 23 253
[17]	Thomas R, Richard L, An K N 2003 J. Biome. Chan. 36 1917
[18]	McKnight A, Kugel J, Rossman P, Manduca A, Hartmann L, Ehman R 2002 AJR 178 1411
[19]	Sinkus R, Tanter M, Xydeas T, Catheline S, Bercoff J, Fink M 2005 Magn. Reso. Imag. 23 159
[20]	Plewes B, Bishop J, Samani A, Sciarretta J 2000 Phys. Med. Biol. 45 1591
[21]	Bao S L, Gao S, Zhang S G, Zhou K, Zu Z L 2008 Chin. Phys. B 17 328
[22]	Wang H, Li G Y 2005 Acta Phys. Sin. 54 1431 (in Chinese) [王鹤、李鲠颖 2005 54 1431]
[23]	Luo J, Ren T T, Sun X P, Zhan M S 2009 Chin. Phys. 11 4711
[24]	Oida T, Amano A, Matsuda T 2004 International Conference on Informatics Research for Development of Knowledge Society Infrastructure (ICKS' 04 ) Japan, 1—2 March, 2004 p57
[25]	Oudry J, Chen J, Glaser K, Miette V, Sandrin L,Ehman R 2009 J. Magn. Reson. Im. 30 1145

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