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Suppression of spiral waves and spatiotemporal chaos in cardiac tissue has been considered based on the LuoRudy 91 model. To suppress spiral waves and spatiotemporal chaos, the control strategy which employs calcium channel agonist to enhance the maximum conductivity of the slow inward calcium current is proposed. The numerical results show that the method can effectively suppress the spiral wave and spatiotemporal chaos in cardiac tissue even if the distribution of the time-dependent potassium current is non-uniform. The control mechanism has been analyzed.
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Keywords:
- spiral waves /
- spatiotemporal chaos /
- calcium current
[1] ［1］Martyn P N , Alexander V P 2004 Prog.Biophys. Mol. Bio. 85 501
[2] ［2］Liu S Q , Lu Q S , Wang Q 1998 Acta Phys. Sin. 47 1057(in Chinese) ［刘深泉、陆启韶、王琪 1998 47 1057］
[3] ［3］Ma J, Jin W Y, Li Y L, Chen Y 2007 Acta Phys. Sin. 56 2456 (in Chinese) ［马军、靳伍银、李延龙、陈勇 2007 56 2456］
[4] ［4］Zhang G Y, Ma J, Gan Z N, Chen Y 2008 Acta Phys. Sin. 57 6815(in Chinese) ［张国勇、马军、甘正宁、陈勇 2008 57 6815］
[5] ［5］Yi X Z, Liu Y 2008 Acta Phys. Sin. 57 6844 (in Chinese) ［尹小舟、刘勇 2008 57 6844］
[6] ［6］Deng M Y, Shi J, Li H B, Kong L J, Liu M R 2007 Acta Phys. Sin. 56 2012(in Chinese) ［邓敏艺、施娟、李华兵、孔令江、刘慕仁 2007 56 2012］
[7] ［7］Ma J, Jin W Y, Yi M, Li Y L 2008 Acta Phys. Sin. 57 2832(in Chinese) ［马军、靳伍银、易鸣、李延龙 2007 57 2832］
[8] ［8］Ma J, Pu Z S, Feng W J, Li W X 2005 Acta Phys. Sin. 54 4602(in Chinese) ［马军、蒲忠胜、冯旺军、李维学 2005 54 4602］
[9] ［9］Qu Z L, Weiss J N 2005 Am. J. Physiol Heart Circ Physiol 289 1692
[10] ］Garfinkel A, Kim Y H, Voroshilovsky O, Qu Z L, Kil J R, Lee M H，Karagueuzian H S, Weiss J N, Chen P S 2000 PANS 97 6061
[11] ］Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss J N, Olcese R 2007 Am. J. Physiol Heart Circ Physiol 293 1805
[12] ］Qu Z L, Weiss J N, Garfinkel A 1999 Am. J. Physiol Heart Circ Physiol 276 269
[13] ］Kamiya K, Nishiyama A,Yasui K, Hojo M, Sanguinetti M C, Kodama I 2001 Circulation 103 1317
[14] ］Luo C, Rudy Y 1991 Circ. Res. 68 1501
[15] ］Zhou Z Y, Lan T J, Li H Y, Zhang Y, Wang Y F 1995 Journal of West China University of Medical Sciences 26 287 (in Chinese)［周祖玉、蓝庭剑、李红宇、张玉、王用芬 1995 华西医大学报 26 287］
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[1] ［1］Martyn P N , Alexander V P 2004 Prog.Biophys. Mol. Bio. 85 501
[2] ［2］Liu S Q , Lu Q S , Wang Q 1998 Acta Phys. Sin. 47 1057(in Chinese) ［刘深泉、陆启韶、王琪 1998 47 1057］
[3] ［3］Ma J, Jin W Y, Li Y L, Chen Y 2007 Acta Phys. Sin. 56 2456 (in Chinese) ［马军、靳伍银、李延龙、陈勇 2007 56 2456］
[4] ［4］Zhang G Y, Ma J, Gan Z N, Chen Y 2008 Acta Phys. Sin. 57 6815(in Chinese) ［张国勇、马军、甘正宁、陈勇 2008 57 6815］
[5] ［5］Yi X Z, Liu Y 2008 Acta Phys. Sin. 57 6844 (in Chinese) ［尹小舟、刘勇 2008 57 6844］
[6] ［6］Deng M Y, Shi J, Li H B, Kong L J, Liu M R 2007 Acta Phys. Sin. 56 2012(in Chinese) ［邓敏艺、施娟、李华兵、孔令江、刘慕仁 2007 56 2012］
[7] ［7］Ma J, Jin W Y, Yi M, Li Y L 2008 Acta Phys. Sin. 57 2832(in Chinese) ［马军、靳伍银、易鸣、李延龙 2007 57 2832］
[8] ［8］Ma J, Pu Z S, Feng W J, Li W X 2005 Acta Phys. Sin. 54 4602(in Chinese) ［马军、蒲忠胜、冯旺军、李维学 2005 54 4602］
[9] ［9］Qu Z L, Weiss J N 2005 Am. J. Physiol Heart Circ Physiol 289 1692
[10] ］Garfinkel A, Kim Y H, Voroshilovsky O, Qu Z L, Kil J R, Lee M H，Karagueuzian H S, Weiss J N, Chen P S 2000 PANS 97 6061
[11] ］Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss J N, Olcese R 2007 Am. J. Physiol Heart Circ Physiol 293 1805
[12] ］Qu Z L, Weiss J N, Garfinkel A 1999 Am. J. Physiol Heart Circ Physiol 276 269
[13] ］Kamiya K, Nishiyama A,Yasui K, Hojo M, Sanguinetti M C, Kodama I 2001 Circulation 103 1317
[14] ］Luo C, Rudy Y 1991 Circ. Res. 68 1501
[15] ］Zhou Z Y, Lan T J, Li H Y, Zhang Y, Wang Y F 1995 Journal of West China University of Medical Sciences 26 287 (in Chinese)［周祖玉、蓝庭剑、李红宇、张玉、王用芬 1995 华西医大学报 26 287］
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