The phase-preserving amplitude regeneration scheme based on the bidirectional orthogonal-pumped semiconductor optical amplifier (SOA) is proposed in this work. Experimental investigation into the multiple four-wave mixing (FWM) process from the pump, the signal and their corresponding reflective fields is carried out in detail. The regeneration performance obtained from the product between co-propagating fields is also discussed, including its dependence on the signal launch power and the signal quality, to quantify the amplitude regeneration and the phase preserving behaviors. The amplitude distortion is suppressed by 2.2 dB experimentally, confirming the regeneration capability of the proposed scheme. Moreover, the regeneration performance is further investigated for multiple phase shift keying (MPSK) signals through the simulation. According to the numerical results, the operational parameters of the regenerator are the same for advanced modulation formats, proving the robust operation of the proposed bidirectional orthogonal-pumped SOA configuration.